Preparation of drug-immobilized anti-adhesion agent using visible light-curable alginate derivative containing furfuryl group
DC Field | Value | Language |
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dc.contributor.author | Noh, Seung-Hyun | - |
dc.contributor.author | Kim, Shin-Woong | - |
dc.contributor.author | Kim, Jae-Won | - |
dc.contributor.author | Lee, Tae-Hoon | - |
dc.contributor.author | Nah, Jae-Woon | - |
dc.contributor.author | Lee, Young-Gi | - |
dc.contributor.author | Kim, Mi-Kyung | - |
dc.contributor.author | Ito, Yoshihiro | - |
dc.contributor.author | Son, Tae-Il | - |
dc.date.available | 2019-05-28T02:46:44Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.issn | 1879-0003 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18356 | - |
dc.description.abstract | This study demonstrated the anti-adhesion and wound healing effect of a visible light curable anti-adhesion agent using an alginate derivative modified with a furfuryl moiety. Visible light-curable furfuryl alginate (F-Alg) was prepared in conjugation with alginate and furfutylamine by an amide coupling reaction, and the conjugated F-Alg was characterized by H-1 NMR analysis. The cytotoxicity, cell adhesion, and cell permeability of the F-Alg were evaluated for use in anti-adhesion applications. Drug immobilization and protein release were assessed to verify whether the alginate derivatives and drugs were photo-immobilized. In in vivo anti-adhesion testing, the new anti-adhesion agent prepared in this study acted as a physical protective layer by forming a biofilm on the surgical site. Additionally, along with gradual decomposition of the photo-crosslinked alginate derivative, the immobilized drug was released, and additional effects such as accelerated wound healing are expected. Thus, visible light-curable F-Alg has good application potential as an anti-adhesion agent. (C) 2018 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Preparation of drug-immobilized anti-adhesion agent using visible light-curable alginate derivative containing furfuryl group | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2018.09.195 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.121, pp 301 - 308 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000452346100036 | - |
dc.identifier.scopusid | 2-s2.0-85054566621 | - |
dc.citation.endPage | 308 | - |
dc.citation.startPage | 301 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.citation.volume | 121 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Alginate | - |
dc.subject.keywordAuthor | Anti-adhesion | - |
dc.subject.keywordAuthor | Furfuryl group | - |
dc.subject.keywordAuthor | Riboflavin | - |
dc.subject.keywordAuthor | Visible light | - |
dc.subject.keywordPlus | SODIUM ALGINATE | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | ADHESION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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