p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats
- Authors
- Lee, Jong Hyuk; Chung, Yoon Hee; Kim, Ho Hyun; Bang, Joon Seok; Jung, Tae Woo; Park, Taekwang; Park, Jinwoo; Kim, Uiseok; Lee, Sung Hoon; Jeong, Ji Hoon
- Issue Date
- Nov-2018
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- P-coumaric acid; Tibial length; Growth plate; Proliferation; Insulin-like growth factor
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.505, no.4, pp 1103 - 1106
- Pages
- 4
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 505
- Number
- 4
- Start Page
- 1103
- End Page
- 1106
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1845
- DOI
- 10.1016/j.bbrc.2018.10.046
- ISSN
- 0006-291X
1090-2104
- Abstract
- The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2'-deoxyuridine-positive cells relative to total proliferative cells. Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. These results suggest that p-coumaric acid has the potential to increase height and may be a feasible alternative to growth hormone therapy. (C) 2018 Elsevier Inc. All rights reserved.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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