Recent advances in intra-articular drug delivery systems to extend drug retention in joint
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ho, M.J. | - |
dc.contributor.author | Kim, S.R. | - |
dc.contributor.author | Choi, Y.W. | - |
dc.contributor.author | Kang, M.J. | - |
dc.date.available | 2019-05-28T03:33:20Z | - |
dc.date.issued | 2019-01-15 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18498 | - |
dc.description.abstract | Intra-articular (IA) administration of therapeutic agents has been employed to selectively deliver active compounds at their site of action for the treatment of chronic joint diseases such as osteoarthritis, rheumatoid arthritis, and joint pain. Direct IA delivery of active compounds to local tissues occasionally provides improved therapeutic outcomes with reduced dose, while minimizing systemic exposure and undesirable adverse effects. However, many small drugs (< 10,000 Da) administered intra-articularly, tend to be rapidly effluxed from the synovium into the blood stream, thus requiring frequent IA injection. To date, different pharmaceutical approaches have been investigated, including polymer and/or lipid-based nanoparticles (NPs), microparticles (MPs), conventional and/or thermo-responsive hydrogels, drug suspension, and oily depot systems, to prolong the drug retention time in the joint, thus improving the pharmacokinetic profile and/or the therapeutic efficacy of active compounds. Herein, we have summarized the recent research trends on IA delivery systems with a focus on NPs, MPs, and hydrogel system, which have been studied most extensively to achieve extended retention time following IA injection. © 2018, The Korean Society of Pharmaceutical Sciences and Technology. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Netherlands | - |
dc.title | Recent advances in intra-articular drug delivery systems to extend drug retention in joint | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s40005-018-0383-7 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Investigation, v.49, no.1, pp 9 - 15 | - |
dc.identifier.kciid | ART002433324 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85059325832 | - |
dc.citation.endPage | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.title | Journal of Pharmaceutical Investigation | - |
dc.citation.volume | 49 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hydrogels | - |
dc.subject.keywordAuthor | Intra-articular drug delivery | - |
dc.subject.keywordAuthor | Joints | - |
dc.subject.keywordAuthor | Microparticles | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Prolonged release | - |
dc.subject.keywordPlus | celecoxib | - |
dc.subject.keywordPlus | liposome | - |
dc.subject.keywordPlus | microparticle | - |
dc.subject.keywordPlus | nanocarrier | - |
dc.subject.keywordPlus | nanoparticle | - |
dc.subject.keywordPlus | polymeric microparticle | - |
dc.subject.keywordPlus | polymeric nanoparticle | - |
dc.subject.keywordPlus | solid lipid nanoparticle | - |
dc.subject.keywordPlus | triamcinolone acetonide | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | arthralgia | - |
dc.subject.keywordPlus | arthropathy | - |
dc.subject.keywordPlus | drug clearance | - |
dc.subject.keywordPlus | drug concentration | - |
dc.subject.keywordPlus | drug delivery system | - |
dc.subject.keywordPlus | drug half life | - |
dc.subject.keywordPlus | drug penetration | - |
dc.subject.keywordPlus | drug release | - |
dc.subject.keywordPlus | drug retention | - |
dc.subject.keywordPlus | flow rate | - |
dc.subject.keywordPlus | gelation | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hydrogel | - |
dc.subject.keywordPlus | intraarticular drug administration | - |
dc.subject.keywordPlus | membrane permeability | - |
dc.subject.keywordPlus | osteoarthritis | - |
dc.subject.keywordPlus | outcome assessment | - |
dc.subject.keywordPlus | particle size | - |
dc.subject.keywordPlus | patient compliance | - |
dc.subject.keywordPlus | pharmacokinetic parameters | - |
dc.subject.keywordPlus | physical chemistry | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | Review | - |
dc.subject.keywordPlus | rheumatoid arthritis | - |
dc.subject.keywordPlus | static electricity | - |
dc.subject.keywordPlus | suspension | - |
dc.subject.keywordPlus | synovial fluid level | - |
dc.subject.keywordPlus | temperature sensitivity | - |
dc.subject.keywordPlus | thermal conductivity | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.