Near infrared light-responsive heat-emitting hemoglobin hydrogels for photothermal cancer therapy
DC Field | Value | Language |
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dc.contributor.author | Lee, C. | - |
dc.contributor.author | Lim, K. | - |
dc.contributor.author | Kim, S.S. | - |
dc.contributor.author | Thien, L.X. | - |
dc.contributor.author | Lee, E.S. | - |
dc.contributor.author | Oh, K.T. | - |
dc.contributor.author | Choi, H.-G. | - |
dc.contributor.author | Youn, Y.S. | - |
dc.date.available | 2019-05-28T03:34:11Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18527 | - |
dc.description.abstract | Photothermal therapy (PTT) is an effective means of treating tumors because tumor cells are sensitive to heat. Gold and carbon nanoparticles are used as efficient PTT materials. However, development of a non-toxic biodegradable PTT agent remains a challenge. Here, we developed a hemoglobin (Hb) hydrogel that exhibited excellent PTT effects in vitro and in vivo. Unlike conventional PTT agents, which are toxic and do not decompose completely in the body, the Hb hydrogel was manufactured using only two components: (i) Hb, a natural substance derived from the human body, and (ii) PEG, an FDA-approved polymer. The gelation time of the Hb hydrogels could be controlled by changing the Hb concentration. Because Hb is present at a high concentration (150 mg/ml) in the body, the Hb hydrogel decomposed and was eliminated in vivo without toxicity. The Hb hydrogel showed an excellent PTT effect in response to 808 nm near-infrared (NIR) laser irradiation and had excellent anticancer effects against A549 lung cancer cells both in vitro and in vivo. Blood hematology and blood biochemical assay results from an animal model treated with Hb hydrogel were similar to those of the control group. Importantly, toxicity was not observed based on H&E staining of major organs (heart, liver, spleen, kidneys and lung). Tumors of A549 cell-xenografted mice treated with Hb hydrogel and 808 nm NIR laser irradiation were significantly smaller than those of the control group (23.1 mm 3 versus 746.5 mm 3 , respectively). This is a first report of a biocompatible photothermal hydrogel based on hemoglobin, and our overall results suggest that Hb hydrogels are commercially-promising PTT systems that have excellent anti-cancer effects. © 2018 Elsevier B.V. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Near infrared light-responsive heat-emitting hemoglobin hydrogels for photothermal cancer therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2018.12.070 | - |
dc.identifier.bibliographicCitation | Colloids and Surfaces B: Biointerfaces, v.176, pp 156 - 166 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000465051800019 | - |
dc.identifier.scopusid | 2-s2.0-85059344751 | - |
dc.citation.endPage | 166 | - |
dc.citation.startPage | 156 | - |
dc.citation.title | Colloids and Surfaces B: Biointerfaces | - |
dc.citation.volume | 176 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Biocompatibility | - |
dc.subject.keywordAuthor | Hemoglobin | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Photothermal therapy | - |
dc.subject.keywordAuthor | Quick gelation | - |
dc.subject.keywordPlus | Biocompatibility | - |
dc.subject.keywordPlus | Biological organs | - |
dc.subject.keywordPlus | Blood | - |
dc.subject.keywordPlus | Diseases | - |
dc.subject.keywordPlus | Gelation | - |
dc.subject.keywordPlus | Hemoglobin | - |
dc.subject.keywordPlus | Infrared devices | - |
dc.subject.keywordPlus | Irradiation | - |
dc.subject.keywordPlus | Mammals | - |
dc.subject.keywordPlus | Toxicity | - |
dc.subject.keywordPlus | Tumors | - |
dc.subject.keywordPlus | Anticancer effects | - |
dc.subject.keywordPlus | Carbon Nano-Particles | - |
dc.subject.keywordPlus | Lung Cancer | - |
dc.subject.keywordPlus | Near infrared light | - |
dc.subject.keywordPlus | Near-infrared lasers | - |
dc.subject.keywordPlus | NIR laser irradiation | - |
dc.subject.keywordPlus | Photothermal cancer therapy | - |
dc.subject.keywordPlus | Photothermal therapy | - |
dc.subject.keywordPlus | Hydrogels | - |
dc.subject.keywordPlus | hemoglobin | - |
dc.subject.keywordPlus | A-549 cell line | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | biocompatibility | - |
dc.subject.keywordPlus | biodegradation | - |
dc.subject.keywordPlus | cancer therapy | - |
dc.subject.keywordPlus | cell viability | - |
dc.subject.keywordPlus | clinical effectiveness | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytotoxicity | - |
dc.subject.keywordPlus | hemoglobin determination | - |
dc.subject.keywordPlus | hydrogel | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | lung cancer | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | outcome assessment | - |
dc.subject.keywordPlus | photothermal therapy | - |
dc.subject.keywordPlus | priority journal | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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