Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Youngnam | - |
dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Lee, Yeong Mi | - |
dc.contributor.author | Im, Sooseok | - |
dc.contributor.author | Park, Hansoo | - |
dc.contributor.author | Kim, Won Jong | - |
dc.date.available | 2019-05-28T11:31:56Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19057 | - |
dc.description.abstract | This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jconrel.2015.08.057 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.220, pp 624 - 630 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000368021100008 | - |
dc.identifier.scopusid | 2-s2.0-84949495537 | - |
dc.citation.endPage | 630 | - |
dc.citation.startPage | 624 | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 220 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Wound healing | - |
dc.subject.keywordAuthor | Ointment | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | N-diazeniumdiolate | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.