수유불내증 신생아에서 Erythromycin과 Metoclopramide의 효능 비교Efficacy of Erythromycin and Metoclopramide in Neonates with Feeding Intolerance
- Authors
- 서경아; 이나미; 최응상; 유병훈
- Issue Date
- 2013
- Publisher
- 대한신생아학회
- Keywords
- Erythromycin; Feeding intolerance; Metoclopramide; Neonate
- Citation
- Neonatal medicine, v.20, no.4, pp 462 - 469
- Pages
- 8
- Journal Title
- Neonatal medicine
- Volume
- 20
- Number
- 4
- Start Page
- 462
- End Page
- 469
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19182
- DOI
- 10.5385/nm.2013.20.4.462
- ISSN
- 2287-9412
2287-9803
- Abstract
- Purpose: Feeding intolerance is common in premature infants. It may extend the parenteral nutrition period and increase the risk of complications. We evaluated the efficacy of erythromycin and metoclopramide in neonates with feeding intolerance.
Methods: Between December 2006 to August 2011, 114 neonates with feeding intolerance were divided into two groups treated with either erythromycin or metoclopramide in the neonatal intensive care unit of Chung-ang University Hospital, a tertiary care center. We defined neonates with feeding intolerance as those who either could not be fully fed enterally (120 mL/kg/day) within 7 days or who skipped feeding more than twice per day because the gastric residual volume was >20% of each feed or more than 50% once. The time taken to achieve 50%, 75%, and 100% enteral feeding was estimated retrospectively.
Results: The erythromycin group achieved 50% feeding (P=0.047), 75% feeding (P=0.042), and 100% feeding (P=0.039) earlier than the metoclopramide group. The erythromycin group achieved 100% feeding earlier than the metoclopramide group among infants with birth weight ≥1,500 g (P=0.036) and those with gestational age ≥ 34 weeks (P=0.008).
Conclusion: Compared with metoclopramide, erythromycin improves feeding in neonates with feeding intolerance, especially in infants with birth weight ≥1,500 g and in those with gestational age ≥34 weeks.
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