In Vitro Inhibitory Mechanism Effect of TRAIP on the Function of TRAF2 Revealed by Characterization of Interaction Domains
DC Field | Value | Language |
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dc.contributor.author | Bhat, Eijaz Ahmed | - |
dc.contributor.author | Kim, Chang Min | - |
dc.contributor.author | Kim, Sunghwan | - |
dc.contributor.author | Park, Hyun Ho | - |
dc.date.available | 2019-03-07T04:36:18Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1938 | - |
dc.description.abstract | TRAF-interacting protein (TRAIP), a negative regulator of TNF-induced-nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) activation, inhibits adaptor protein TRAF2 by direct interaction and is critical in apoptosis, cell proliferation, antiviral response, and embryonic development. Although the critical function of TRAIP in NF-kappa B signaling is well-known, the molecular inhibitory mechanism of TRAIP remains unclear. We found that the TRAIP coiled-coil domain altered its stoichiometry between dimer and trimer in a concentration-dependent manner. Additionally, the TRAIP RING domain induced even higher-ordered assembly, which was necessary for interacting with the TRAF-N domain of TRAF2 but not TRAF1. Characterization of the TRAF-N domains of TRAF1 and TRAF2, the tentative TRAIP-binding region of TRAFs, suggested the molecular basis of the inhibitory effect of TRAIP on TRAF2 in NF-kappa B signaling. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | In Vitro Inhibitory Mechanism Effect of TRAIP on the Function of TRAF2 Revealed by Characterization of Interaction Domains | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms19082457 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.8 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000442869800309 | - |
dc.identifier.scopusid | 2-s2.0-85052147735 | - |
dc.citation.number | 8 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | immune response | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | tumor necrosis factor-receptor associated factor | - |
dc.subject.keywordAuthor | TRAF-interacting protein | - |
dc.subject.keywordAuthor | protein interaction | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | FACTOR RECEPTOR | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ADAPTER PROTEINS | - |
dc.subject.keywordPlus | MOLECULAR-BASIS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | TRIP | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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