항-N-methyl-D-aspartate수용체 항체 양성인 엡스타인-바바이러스뇌간뇌염Epstein-Barr Virus Brainstem Encephalitis With Anti-N-methyl-D-aspartate Receptor Antibodies
- Authors
- 임정아; 변정익; 이순태; 정근화; 김영수; 김정민; 이상건; 주건
- Issue Date
- 2013
- Publisher
- 대한신경과학회
- Keywords
- Encephalitis; Epstein-Barr virus; N-Methyl-D-aspartate
- Citation
- 대한신경과학회지, v.31, no.3, pp 199 - 202
- Pages
- 4
- Journal Title
- 대한신경과학회지
- Volume
- 31
- Number
- 3
- Start Page
- 199
- End Page
- 202
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19678
- ISSN
- 1225-7044
- Abstract
- The neurological manifestations caused by Epstein-Barr virus (EBV) occur only rarely in association with its primary infection or reactivation. The mechanism by which EBV produces neurological disease is unknown. This article describes two cases of polymerase-chain-reaction-proven EBV brainstem encephalitis. The sera of both patients contained autoantibodies against N-methyl-D-aspartate receptor (NMDAR), suggesting the presence of a secondary immunological mechanism. Prospective studies are needed to reveal whether the subgroup of patients with EBV encephalitis and anti-NMDAR antibodies have different clinical presentations and would benefit from immunotherapy.
The neurological manifestations caused by Epstein-Barr virus (EBV) occur only rarely in association with its primary infection or reactivation. The mechanism by which EBV produces neurological disease is unknown. This article describes two cases of polymerase-chain-reaction-proven EBV brainstem encephalitis. The sera of both patients contained autoantibodies against N-methyl-D-aspartate receptor (NMDAR), suggesting the presence of a secondary immunological mechanism. Prospective studies are needed to reveal whether the subgroup of patients with EBV encephalitis and anti-NMDAR antibodies have different clinical presentations and would benefit from immunotherapy.
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