Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures
DC Field | Value | Language |
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dc.contributor.author | Ruusuvuori, Eva | - |
dc.contributor.author | Huebner, Antje K | - |
dc.contributor.author | Kirilkin, Ilya | - |
dc.contributor.author | Yukin, Alexey Y | - |
dc.contributor.author | Blaesse,Peter | - |
dc.contributor.author | Helmy, Mohamed | - |
dc.contributor.author | Kang, Hyo Jung | - |
dc.contributor.author | El Muayed, Muayed | - |
dc.contributor.author | Christopher Hennings, J. | - |
dc.contributor.author | Voipio, Juha | - |
dc.contributor.author | Šestan, Nenad | - |
dc.contributor.author | Hübner, Christian A | - |
dc.contributor.author | Kaila, Kai | - |
dc.date.available | 2019-05-29T03:39:12Z | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.issn | 1460-2075 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19885 | - |
dc.description.abstract | Brain carbonic anhydrases (CAs) are known to modulate neuronal signalling. Using a novel CA VII (Car7) knockout (KO) mouse as well as a CA II (Car2) KO and a CA II/VII double KO, we show that mature hippocampal pyramidal neurons are endowed with two cytosolic isoforms. CA VII is predominantly expressed by neurons starting around postnatal day 10 (P10). The ubiquitous isoform II is expressed in neurons at P20. Both isoforms enhance bicarbonate-driven GABAergic excitation during intense GABAA-receptor activation. P13-14 CA VII KO mice show behavioural manifestations atypical of experimental febrile seizures (eFS) and a complete absence of electrographic seizures. A low dose of diazepam promotes eFS in P13-P14 rat pups, whereas seizures are blocked at higher concentrations that suppress breathing. Thus, the respiratory alkalosis-dependent eFS are exacerbated by GABAergic excitation. We found that CA VII mRNA is expressed in the human cerebral cortex before the age when febrile seizures (FS) occur in children. Our data indicate that CA VII is a key molecule in age-dependent neuronal pH regulation with consequent effects on generation of FS. © 2013 European Molecular Biology Organization. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/emboj.2013.160 | - |
dc.identifier.bibliographicCitation | EMBO Journal, v.32, no.16, pp 2275 - 2286 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000323178900009 | - |
dc.identifier.scopusid | 2-s2.0-84882453421 | - |
dc.citation.endPage | 2286 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 2275 | - |
dc.citation.title | EMBO Journal | - |
dc.citation.volume | 32 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Carbonic anhydrase expression | - |
dc.subject.keywordAuthor | Chloride accumulation | - |
dc.subject.keywordAuthor | GABAA receptor | - |
dc.subject.keywordAuthor | Human brain | - |
dc.subject.keywordAuthor | Hyperthermia | - |
dc.subject.keywordPlus | 4 aminobutyric acid A receptor | - |
dc.subject.keywordPlus | carbonate dehydratase | - |
dc.subject.keywordPlus | carbonate dehydratase VII | - |
dc.subject.keywordPlus | diazepam | - |
dc.subject.keywordPlus | ionotropic receptor | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | picrotoxin | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | alkalinization | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | depolarization | - |
dc.subject.keywordPlus | disease exacerbation | - |
dc.subject.keywordPlus | febrile convulsion | - |
dc.subject.keywordPlus | GABAergic system | - |
dc.subject.keywordPlus | genotype | - |
dc.subject.keywordPlus | hippocampus | - |
dc.subject.keywordPlus | hyperpolarization | - |
dc.subject.keywordPlus | LoxP site | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | neocortex | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | postnatal development | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | pyramidal nerve cell | - |
dc.subject.keywordPlus | respiratory alkalosis | - |
dc.subject.keywordPlus | seizure susceptibility | - |
dc.subject.keywordPlus | synaptic transmission | - |
dc.subject.keywordPlus | tonic clonic seizure | - |
dc.subject.keywordPlus | upregulation | - |
dc.subject.keywordPlus | Age Factors | - |
dc.subject.keywordPlus | Analysis of Variance | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Blotting, Northern | - |
dc.subject.keywordPlus | Blotting, Western | - |
dc.subject.keywordPlus | Carbonic Anhydrase II | - |
dc.subject.keywordPlus | Carbonic Anhydrases | - |
dc.subject.keywordPlus | Cerebral Cortex | - |
dc.subject.keywordPlus | Diazepam | - |
dc.subject.keywordPlus | Electroencephalography | - |
dc.subject.keywordPlus | Fluorescence | - |
dc.subject.keywordPlus | GABAergic Neurons | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Hydrogen-Ion Concentration | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Knockout | - |
dc.subject.keywordPlus | Rats | - |
dc.subject.keywordPlus | Seizures, Febrile | - |
dc.subject.keywordPlus | Mus | - |
dc.subject.keywordPlus | Rattus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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