Genetic factors in frontotemporal dementia: A review
DC Field | Value | Language |
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dc.contributor.author | Shen, L. | - |
dc.contributor.author | Bagyinszky, E. | - |
dc.contributor.author | Youn, Y.C. | - |
dc.contributor.author | An, S.S.A. | - |
dc.contributor.author | Kim, S.Y. | - |
dc.date.available | 2019-05-29T03:39:25Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 2005-9752 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19893 | - |
dc.description.abstract | Frontotemporal dementia (FTD) is the second most common form of neurogenerative dementia, following Alzheimer's disease (AD). FTD is a clinically and phenotypically heterogeneous disorder, which occurs mostly in younger patients under 60 years of age. Several genes were described to be involved in FTD: progranulin (PGRN), microtubule-associated protein tau (MAPT), chromosome 9 open reading frame 72 (C9orf72), fused in sarcoma (FUS), TAR DNA binding protein-43 (TARDBP), valosin-containing protein (VCP), and charged multivesicular body protein 2B (CHMP 2B). Genome-wide association studies (GWAS) identified additional putative FTD risk factor genes, such as transmembrane protein 106B (TMEM106B) or ubiquilin-2 (UBQLN2). Improvements in genetic analysis could enhance the differential diagnosis for neurodegenerative disorders, especially FTD. This review summarized the FTD-associated genes, mutations and the latest methods for genetic analysis. © 2013 Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht. | - |
dc.format.extent | 18 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Genetic factors in frontotemporal dementia: A review | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13530-013-0165-6 | - |
dc.identifier.bibliographicCitation | Toxicology and Environmental Health Sciences, v.5, no.3, pp 113 - 130 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84886745901 | - |
dc.citation.endPage | 130 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 113 | - |
dc.citation.title | Toxicology and Environmental Health Sciences | - |
dc.citation.volume | 5 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | C9orf72 | - |
dc.subject.keywordAuthor | CHMP2B | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | FTD | - |
dc.subject.keywordAuthor | FUS | - |
dc.subject.keywordAuthor | MAPT | - |
dc.subject.keywordAuthor | Mutation | - |
dc.subject.keywordAuthor | PGRN | - |
dc.subject.keywordAuthor | TARDBP | - |
dc.subject.keywordAuthor | VCP | - |
dc.subject.keywordPlus | charged multivesicular body protein 2B | - |
dc.subject.keywordPlus | chromosome 9 open reading frame 72 | - |
dc.subject.keywordPlus | fused in sarcoma | - |
dc.subject.keywordPlus | peptides and proteins | - |
dc.subject.keywordPlus | progranulin | - |
dc.subject.keywordPlus | TAR DNA binding protein | - |
dc.subject.keywordPlus | tau protein | - |
dc.subject.keywordPlus | transmembrane protein 106B | - |
dc.subject.keywordPlus | ubiquilin 2 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | valosin containing protein | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | amyotrophic lateral sclerosis | - |
dc.subject.keywordPlus | exon | - |
dc.subject.keywordPlus | frontotemporal dementia | - |
dc.subject.keywordPlus | gene mutation | - |
dc.subject.keywordPlus | genetic association | - |
dc.subject.keywordPlus | heredity | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | review | - |
dc.subject.keywordPlus | risk factor | - |
dc.description.journalRegisteredClass | scopus | - |
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