A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging
DC Field | Value | Language |
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dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Lim, Chaemin | - |
dc.contributor.author | Song, Ho-Taek | - |
dc.contributor.author | Yun, Jeong Min | - |
dc.contributor.author | Lee, Kyung Soo | - |
dc.contributor.author | Lee, Beom-Jin | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Oh, Young Taik | - |
dc.contributor.author | Oh, Kyung Teak | - |
dc.date.available | 2019-05-29T03:40:39Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19933 | - |
dc.description.abstract | Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively investigated as MRI probes due to the noninvasive detection of in vivo pathological changes. In the study, a nanosized system for SPIO delivery to a tumor was prepared to overcome the common challenges of SPIO nanoparticles such as insufficient uptake of SPIO by specific cells due to instability, short half-life by macrophage, and low efficiency of internalization. SPIO with ca. 6 nm sizes as a MRI probe and PLA-PEG (5K-2K) as a bio-compatible stable system were prepared. The hydrophobic modified SPIO were loaded into the core of micelles and showed a stable dispersion with 140-170 nm particle sizes. The SPIO loading micelles showed higher relaxivity coefficients and increases of T-2 relaxation in vivo MR imaging. This SPIO delivery system with high stability and sensitivity can be a promising imaging formulation as MRI T-2 probes for tumor detection. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijpharm.2012.08.054 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.439, no.1-2, pp 342 - 348 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000311151100042 | - |
dc.identifier.scopusid | 2-s2.0-84869491808 | - |
dc.citation.endPage | 348 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 342 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 439 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Polymeric micelle | - |
dc.subject.keywordAuthor | Superparamagnetic iron oxide (SPIO) | - |
dc.subject.keywordAuthor | Hyperspectrum | - |
dc.subject.keywordAuthor | T-2 relaxivity coefficients | - |
dc.subject.keywordAuthor | Animal imaging | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | ENHANCED PERMEABILITY | - |
dc.subject.keywordPlus | DRUG CARRIERS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | RELAXIVITY | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | COPOLYMERS | - |
dc.subject.keywordPlus | RETENTION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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