Anti-adipogenic effects of 1,25-dihydroxyvitamin D3 are mediated by the maintenance of the wingless-type MMTV integration site/beta-catenin pathway
DC Field | Value | Language |
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dc.contributor.author | Lee, Haeyong | - |
dc.contributor.author | Bae, Sungmin | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.date.available | 2019-05-29T05:35:15Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.issn | 1791-244X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20048 | - |
dc.description.abstract | 1,25-di hydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D, was found to have anti-adipogenic activity, however, its mechanism of action has not been fully elucidated. In this study, 3T3-L1 preadipocytes were differentiated in the presence and absence of 1,25(OH)2D3, and the expression of the genes and proteins of the wingless-type MMTV integral ion site (WNT)/beta-catenin pathway were analyzed. While the expression of the members of the WNT/beta-catenin pathway were significantly downregulated during the adipogenesis of untreated 3T3-L1 cells, 1,25(OH)2D3 treatment was found to maintain the WNT/beta-catenin pathway. Among the members of the WNT/beta-catenin pathway, the levels of WNT10B and disheveled (DVL)2 as well as the phosphorylation of glycogen synthase kinase (GSK)3 beta were maintained by 1,25(OH)2D3 treatment. The levels of nuclear beta-catenin, which were downregulated during adipogenesis, were also maintained by 1,25(OH)2D3 treatment. The results of this study suggested that the anti-adipogenic effect of 1,25(OH)2D3 was mediated by the maintenance of the WNT/beta-catenin pathway, which was normally downregulated during adipogenesis. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Anti-adipogenic effects of 1,25-dihydroxyvitamin D3 are mediated by the maintenance of the wingless-type MMTV integration site/beta-catenin pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/ijmm.2012.1101 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.30, no.5, pp 1219 - 1224 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000310651500033 | - |
dc.identifier.scopusid | 2-s2.0-84866594466 | - |
dc.citation.endPage | 1224 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1219 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 30 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | 1,25-dihydroxyvitamin D3 | - |
dc.subject.keywordAuthor | adipogenesis | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | vitamin D | - |
dc.subject.keywordAuthor | wingless-type MMTV integration site | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | 3T3-L1 CELLS | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | FUNCTIONAL INTERACTION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | WNT10B | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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