Paradoxical response in HIV-negative patients with pleural tuberculosis: a retrospective multicentre study
DC Field | Value | Language |
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dc.contributor.author | Jeon, K. | - |
dc.contributor.author | Choi, W-I. | - |
dc.contributor.author | An, J. S. | - |
dc.contributor.author | Lim, S. Y. | - |
dc.contributor.author | Kirn, W. J. | - |
dc.contributor.author | Park, G. M. | - |
dc.contributor.author | Park, S. S. | - |
dc.contributor.author | Choi, H. S. | - |
dc.contributor.author | Lee, B. H. | - |
dc.contributor.author | Choi, J. C. | - |
dc.contributor.author | Na, M. J. | - |
dc.contributor.author | Park, J. | - |
dc.contributor.author | Kim, J. Y. | - |
dc.date.available | 2019-05-29T07:33:12Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.issn | 1815-7920 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20275 | - |
dc.description.abstract | OBJECTIVE: To evaluate the incidence, clinical characteristics and predicting factors for the development of paradoxical response in human immunodeficiency virus negative patients with isolated pleural tuberculosis (TB). DESIGN: A multicentre, retrospective cohort study including 458 patients who were diagnosed and treated with isolated pleural TB between March 2005 and February 2010. RESULTS: Paradoxical response developed in 72 patients (16%) with isolated pleural TB. The mean time to development of paradoxical response was 8.8 +/- 6.4 weeks after initiation of anti-tuberculosis treatment. The main presentation of paradoxical response was aggravation of pre-existing pleural effusion in 58 patients (81%). However, the majority of the patients who developed paradoxical response had no associated symptoms (n = 49, 68%). In multiple logistic regression analysis, development of paradoxical response was independently associated with the proportion of eosinophils (adjusted OR 1.293, 95%CI 1.077-1.553) and protein concentrations (adjusted OR 0.590, 95%Cl 0.397-0.878) in the pleural fluid at the time of diagnosis. CONCLUSION: Paradoxical response developed in 16% of the patients approximately 2 months after initiation of anti-tuberculosis treatment, presenting with aggravation of pre-existing pleural effusion. Development of paradoxical response was associated with the proportion of eosinophils and protein concentrations in the pleural fluid at the time of diagnosis. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | - |
dc.title | Paradoxical response in HIV-negative patients with pleural tuberculosis: a retrospective multicentre study | - |
dc.type | Article | - |
dc.identifier.doi | 10.5588/ijtld.11.0642 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.16, no.6, pp 846 - 851 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000304580400025 | - |
dc.identifier.scopusid | 2-s2.0-84861178715 | - |
dc.citation.endPage | 851 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 846 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 프랑스 | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis | - |
dc.subject.keywordAuthor | pleural effusion | - |
dc.subject.keywordAuthor | incidence | - |
dc.subject.keywordAuthor | risk factors | - |
dc.subject.keywordPlus | ANTITUBERCULOSIS TREATMENT | - |
dc.subject.keywordPlus | INFECTED PATIENTS | - |
dc.subject.keywordPlus | EFFUSION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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