The Mycobacterium avium subsp paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency
DC Field | Value | Language |
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dc.contributor.author | Noh, Kyung Tae | - |
dc.contributor.author | Shin, Sung Jae | - |
dc.contributor.author | Son, Kwang Hee | - |
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Kang, Hyun Kyu | - |
dc.contributor.author | Lee, Su Jung | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.contributor.author | Shin, Yong Kyoo | - |
dc.contributor.author | You, Ji Chang | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.date.available | 2019-05-29T07:34:28Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20311 | - |
dc.description.abstract | In this study, we showed the direct interaction between Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein (FAP) and toll-like receptor4 (TLR4) via co-localization and binding by using confocal microscopy and co-immunoprecipitation assays. FAP triggered the expression of pro- and anti-inflammatory cytokines in a TLR4-dependent manner. In addition, FAP-induced cytokine expression in bone marrow-derived dendritic cells (BMDCs) was modulated in part by glycogen synthase kinase-3 (GSK-3). FAP-induced expression of CD80, CD86, major histocompatibility complex (MHC) class I, and MHC class II in TLR4(+/+) BMDCs was not observed in TLR4(-/-) BMDCs. Furthermore, FAP induced DC-mediated CD8(+) T cell proliferation and cytotoxic T lymphocyte (CTL) activity, and suppressed tumor growth with DC-based tumor vaccination in EG7 thymoma murine model. Taken together, these results indicate that the TLR4 agonist, FAP, a potential immunoadjuvant for DC-based cancer vaccination, improves the DC-based immune response via the TLR4 signaling pathway. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.title | The Mycobacterium avium subsp paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency | - |
dc.type | Article | - |
dc.identifier.doi | 10.3858/emm.2012.44.5.038 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.44, no.5, pp 340 - 349 | - |
dc.identifier.kciid | ART001661854 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000304896600004 | - |
dc.identifier.scopusid | 2-s2.0-84861642579 | - |
dc.citation.endPage | 349 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 340 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 44 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | dendritic cells | - |
dc.subject.keywordAuthor | FAP-A protein | - |
dc.subject.keywordAuthor | Mycobacterium avium | - |
dc.subject.keywordAuthor | glycogen synthase kinase-3 | - |
dc.subject.keywordAuthor | toll-like receptor 4 | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3 | - |
dc.subject.keywordPlus | BACILLUS-CALMETTE-GUERIN | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | INNATE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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