Structural Analysis of a New Cytotoxic Demethylated Analogue of Neo-N-methylsansalvamide with a Different Peptide Sequence Produced by Fusarium solani Isolated from Potato
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee-Seok | - |
dc.contributor.author | Lee, Chan | - |
dc.date.available | 2019-05-29T07:34:54Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.issn | 1520-5118 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20325 | - |
dc.description.abstract | A novel cytotoxic cyclic pentadepsipeptide, neosansalvamide, was produced by Fusarium solani KCCM90040 isolated from Fusarium-contaminated potato in Korea. The molecular formula of neosansalvamide was analyzed as C32H50N4O6 by electrospray ionization tandem mass spectrometry and combined structural analysis. The one- and two-dimensional nuclear magnetic resonance and absolute configuration of amino acid spectral data allowed for the resolution of cyclic five subunits linked in the following order: (S)-leucic acid, two L-leucine, L-valine, and L-phenylalanine, and this sequence shows a molecular structure as a new demethylated analogue of neo-N-methylsansalvamide but having a different peptide sequence. The cytotoxic effects of neosansalvamide were investigated by sulforhodamine B bioassay on four human cancer cell lines. The IC50 value of neosansalvamide required to inhibit cell growth in vitro by 50% for A549 (lung cancer), SK-OV-3 (ovarian cancer), SK-MEL-2 (skin melanoma), and MES-SA (uterine sarcoma) cell lines were 11.70 +/- 0.55, 10.38 +/- 0.64, 13.99 +/- 1.32, and 11.75 +/- 0.13 mu M, respectively (mean +/- standard error). | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Structural Analysis of a New Cytotoxic Demethylated Analogue of Neo-N-methylsansalvamide with a Different Peptide Sequence Produced by Fusarium solani Isolated from Potato | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jf205217v | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.60, no.17, pp 4342 - 4347 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000303362800023 | - |
dc.identifier.scopusid | 2-s2.0-84860429905 | - |
dc.citation.endPage | 4347 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 4342 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 60 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Neosansalvamide | - |
dc.subject.keywordAuthor | cyclic pentadepsipeptide | - |
dc.subject.keywordAuthor | Fusarium solani | - |
dc.subject.keywordAuthor | cytotoxic activity | - |
dc.subject.keywordPlus | CYCLIC DEPSIPEPTIDE | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | ENNIATIN-H | - |
dc.subject.keywordPlus | GENUS FUSARIUM | - |
dc.subject.keywordPlus | MARINE FUNGUS | - |
dc.subject.keywordPlus | KFCC 11363P | - |
dc.subject.keywordPlus | BEAUVERICIN | - |
dc.subject.keywordPlus | MK1688 | - |
dc.subject.keywordPlus | CYCLODEPSIPEPTIDES | - |
dc.subject.keywordPlus | FUSAPROLIFERIN | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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