Inhibition of Melanogenesis by Xanthium strumarium L.
DC Field | Value | Language |
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dc.contributor.author | Li, Hailan | - |
dc.contributor.author | Min, Young Sil | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.date.available | 2019-05-29T07:38:37Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20432 | - |
dc.description.abstract | Xanthium strumarium L. (Asteraceae) is traditionally used in Korea to treat skin diseases. In this study, we investigated the effects of a X. strumarium stem extract on melanin synthesis. It inhibited melanin synthesis in a concentration-dependent manner, but it did not directly inhibit tyrosinase, the rate-limiting melanogenic enzyme, and instead downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression. MITF, the master regulator of pigmentation, is a target of the Wnt signaling pathway, which includes glycogen synthase kinase 3 beta (GSK3 beta) and beta-catenin. Hence, the influence of X. strumarium stem extract on GSK3 beta and beta-catenin was further investigated. X. strumarium induced GSK3 beta phosphorylation (inactivation), but the level of beta-catenin did not change. Moreover, a specific GSK3 beta inhibitor restored X. strumarium-induced melanin reduction. Hence, we suggest that X. strumarium inhibits melanin synthesis through downregulation of tyrosinase via GSK3 beta phosphorylation. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Inhibition of Melanogenesis by Xanthium strumarium L. | - |
dc.type | Article | - |
dc.identifier.doi | 10.1271/bbb.110894 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.76, no.4, pp 767 - 771 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000304025900021 | - |
dc.identifier.scopusid | 2-s2.0-84860199126 | - |
dc.citation.endPage | 771 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 767 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 76 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | microphthalmia-associated transcription factor (MITF) | - |
dc.subject.keywordAuthor | Xanthium strumarium | - |
dc.subject.keywordAuthor | glycogen synthase kinase 3 beta (GSK3 beta) | - |
dc.subject.keywordPlus | DECREASES MELANIN SYNTHESIS | - |
dc.subject.keywordPlus | SKIN PIGMENTATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | MITF | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | MELANOCYTES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CATENIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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