Molecular Epidemiology of an Outbreak of Imipenem-Resistant Acinetobacter baumannii Carrying the ISAba1-bla(OXA51-like) Genes in a Korean Hospital
- Authors
- Chaulagain, Bidur Prasad; Jang, Sook Jin; Ahn, Gyun Yeol; Ryu, So Yeon; Kim, Dong Min; Park, Geon; Kim, Wonyong; Shin, Jong Hee; Kook, Joong Ki; Kang, Seong-Ho; Moon, Dae Soo; Park, Young Jin
- Issue Date
- Mar-2012
- Publisher
- NATL INST INFECTIOUS DISEASES
- Citation
- JAPANESE JOURNAL OF INFECTIOUS DISEASES, v.65, no.2, pp 162 - 166
- Pages
- 5
- Journal Title
- JAPANESE JOURNAL OF INFECTIOUS DISEASES
- Volume
- 65
- Number
- 2
- Start Page
- 162
- End Page
- 166
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20486
- ISSN
- 1344-6304
1884-2836
- Abstract
- Between January 2004 and December 2004, an outbreak of imipenem-resistant Acinetobacter baumannii (IRAB) in 2 intensive care units (ICU) of Chosun University Hospital, Korea affected 77 patients. A case-control study revealed that the time spent in the hospital and mechanical ventilation practices were risk factors. IRAB was isolated from the hands of 4% (5/124) of healthcare workers, and 27.3% (21/77) of the samples obtained from the ICU environment. A pulsed-field gel electrophoresis analysis showed that 82.1% (23/28) of clinical IRAB isolates and 85.7% (6/7) of environmental IRAB isolates were type A. The ISAba1F/OXA-51-likeR PCR showed that 93.7% (30/32) of IRAB strains had the ISAba1 gene upstream of the bla(OXA-51-like) gene. Two ISAba1F/OXA-51-likeR PCR-negative IRAB strains were bla(IMP-1) positive. All of the IRAB strains tested by PCR were negative for bla(VIM), bla(SIM), bla(GIM-1), bla(SPM-1), bla(GES), bla(OXA-23-like) bla(OXA-24-like) and bla(OXA-58-like) carbapenemase genes. After implementing an infection control strategy, a steady reduction in the attack rate of IRAB infection was observed.
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