Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Nam Muk | - |
dc.contributor.author | Kwag, Dong Sup | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.date.available | 2019-05-29T09:05:49Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20552 | - |
dc.description.abstract | One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.11.026 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.33, no.6, pp 1884 - 1893 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000299986200020 | - |
dc.identifier.scopusid | 2-s2.0-83555177185 | - |
dc.citation.endPage | 1893 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1884 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 33 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Tumor-identifying polypeptide | - |
dc.subject.keywordAuthor | Cancer chemotherapy | - |
dc.subject.keywordAuthor | Tumor extracellular pH | - |
dc.subject.keywordAuthor | Photodynamic therapy | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL POLYMERIC MICELLE | - |
dc.subject.keywordPlus | EXTRACELLULAR PH | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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