Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.date.available | 2019-05-29T09:06:01Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20559 | - |
dc.description.abstract | Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a major ingredient in topical pharmacological agents. However, frequent adverse reactions are amongst its major limitation. To solve this problem, several alternatives such as arbutin, kojic acid, aloesin, and 4-n-butyl resorcinol have been developed. Herein, we classify hypopigmenting agents according to their mechanism of action; a) regulation of enzyme, which is subdivided into three categories, i) regulation of transcription and maturation of tyrosinase, ii) inhibition of tyrosinase activity, and iii) post-transcriptional control of tyrosinase; b) inhibition of melanosome transfer, and c) additional mechanisms such as regulation of the melanocyte environment and antioxidant agents. (Ann Dermatol 24(1) 1 similar to 6, 2012) | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | - |
dc.title | Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action | - |
dc.type | Article | - |
dc.identifier.doi | 10.5021/ad.2012.24.1.1 | - |
dc.identifier.bibliographicCitation | ANNALS OF DERMATOLOGY, v.24, no.1, pp 1 - 6 | - |
dc.identifier.kciid | ART001631893 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000300338700001 | - |
dc.identifier.scopusid | 2-s2.0-84863162166 | - |
dc.citation.endPage | 6 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | ANNALS OF DERMATOLOGY | - |
dc.citation.volume | 24 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hydroquinone | - |
dc.subject.keywordAuthor | Hypopigmentation | - |
dc.subject.keywordAuthor | Melanin | - |
dc.subject.keywordPlus | DECREASES MELANIN SYNTHESIS | - |
dc.subject.keywordPlus | FLUOCINOLONE ACETONIDE 0.01-PERCENT | - |
dc.subject.keywordPlus | TRIPLE-COMBINATION AGENT | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | HUMAN MELANOCYTES | - |
dc.subject.keywordPlus | TRETINOIN 0.05-PERCENT | - |
dc.subject.keywordPlus | HYDROQUINONE 4-PERCENT | - |
dc.subject.keywordPlus | MELANOSOME TRANSFER | - |
dc.subject.keywordPlus | ERK ACTIVATION | - |
dc.subject.keywordPlus | FACIAL MELASMA | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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