Emergence of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Clinical Isolates Among Daptomycin-Naive Patients in Korea
DC Field | Value | Language |
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dc.contributor.author | Nam, Eun Young | - |
dc.contributor.author | Yang, Soo-Jin | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Cho, Jeong Eun | - |
dc.contributor.author | Park, Kyung-Hwa | - |
dc.contributor.author | Jung, Sook-In | - |
dc.contributor.author | Yoon, Nara | - |
dc.contributor.author | Kim, Dong-Min | - |
dc.contributor.author | Lee, Chang-Seop | - |
dc.contributor.author | Jang, Hee-Chang | - |
dc.contributor.author | Park, Yoonseon | - |
dc.contributor.author | Lee, Kkot Sil | - |
dc.contributor.author | Kwak, Yee Gyung | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Park, Seong Yeon | - |
dc.contributor.author | Hwang, Joo-Hee | - |
dc.contributor.author | Kim, Moonsuk | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.date.available | 2019-03-07T04:39:14Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.issn | 1931-8448 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/2075 | - |
dc.description.abstract | This study was conducted to assess emergence of daptomycin-nonsusceptible (DAP-NS) phenotype in DAP-naive patients with invasive Staphylococcus aureus (ISA) infections in Korea. A total of 208 S. aureus clinical isolates were selected from a previous prospective study on ISA infections and evaluated for DAP-NS. Although DAP has never been introduced in Korea, five DAP-NS S. aureus strains (2.4%) were identified among 208 S. aureus strains collected from ISA infections. The DAP-NS phenotype was observed only in methicillin-resistant S. aureus (MRSA) strains, but not in methicillin-susceptible S. aureus strains. One DAP-NS MRSA strain belonged to sequence type 72 (ST72) and four were ST5 MRSA strains, three of which were heteroresistant vancomycin (VAN)-intermediate S. aureus. All these five DAP-NS MRSA strains were from healthcare-associated infections without prior exposure to VAN within 30 days. While the ST72 MRSA strain exhibited DAP-NS phenotype via charge repulsion mechanism, four ST5 DAP-NS S. aureus strains had charge-independent DAP-NS mechanism. None of the five DAP-NS strains displayed significant increase in cell wall thickness, indicating that altered cell wall thickness was not associated with the observed DAP-NS phenotype. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Emergence of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Clinical Isolates Among Daptomycin-Naive Patients in Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/mdr.2017.0212 | - |
dc.identifier.bibliographicCitation | MICROBIAL DRUG RESISTANCE, v.24, no.5, pp 534 - 541 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000414367600001 | - |
dc.identifier.scopusid | 2-s2.0-85048038199 | - |
dc.citation.endPage | 541 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 534 | - |
dc.citation.title | MICROBIAL DRUG RESISTANCE | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | daptomycin resistance | - |
dc.subject.keywordAuthor | Staphylococcus aureus | - |
dc.subject.keywordAuthor | vancomycin | - |
dc.subject.keywordPlus | CATIONIC ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | 2-COMPONENT REGULATORY SYSTEM | - |
dc.subject.keywordPlus | VITRO BACTERICIDAL ACTIVITY | - |
dc.subject.keywordPlus | MOLECULAR CHARACTERIZATION | - |
dc.subject.keywordPlus | REDUCED SUSCEPTIBILITY | - |
dc.subject.keywordPlus | CROSS-RESISTANCE | - |
dc.subject.keywordPlus | VANCOMYCIN | - |
dc.subject.keywordPlus | MPRF | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | BACTEREMIA | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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