Effectofdiets with mulberry leaf and Cudrania tricuspidata leaf powder supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats
DC Field | Value | Language |
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dc.contributor.author | Park, Ju-Hun | - |
dc.contributor.author | Lee, Kyung-Won | - |
dc.contributor.author | Sung, Ki-Seung | - |
dc.contributor.author | Kim, Sung-Soo | - |
dc.contributor.author | Cho, Kyung-Dong | - |
dc.contributor.author | Lee, Bog-Hieu | - |
dc.contributor.author | Han, Chan-Kyu | - |
dc.date.available | 2019-05-29T09:25:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-3311 | - |
dc.identifier.issn | 2288-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20838 | - |
dc.description.abstract | This study investigates the effects of diets with mulberry leaf and Cudrania tricuspidata leaf supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. Male diabetic Sprague-Dawley rats were divided into groups and fed several diets. Group A was fed a diet with a 10% supplement of mulberry leaves. Group B was fed a diet with a 10% supplement of mulberry leaves and an additional 10% supplement of Cudrania tricuspidata leaves. Group C was fed a diet with a 10% supplement of mulberry leaves and an additional 30% supplement of Cudrania tricuspidata leaves. Group D was fed a diet with a 10% supplement of Cudrania tricuspidata leaves. Group E was the DM control. All diets were based on AIN-93G diet and they all lasted 6 weeks. The blood glucose levels of groups B and C stayed similar to initial levels (reference blood glucose) for the experimental period, which was significantly lower than levels in groups A, D, and E at the 6th week (p<0.05). And the area under the blood glucose curve (AUC) was also significantly lower in groups B and C than in groups D and E (p<0.05). The fasting blood glucose level after the experiment was significantly lower in groups B and C (p<0.05), and the C-peptide content of group C was as high as 50 pmol/L on average. The HbA1c content was also significantly lower in groups A and B than in group E (p<0.05). The serum TG, AST, and ALT levels were significantly decreased in groups A, B, and D than in group E (p<0.05). From the findings, it is shown that a diet of 1:1 mulberry and Cudrania tricuspidata leaf supplements could improve blood glucose-related biomarkers. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Food Science and Nutrition | - |
dc.title | Effectofdiets with mulberry leaf and Cudrania tricuspidata leaf powder supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.3746/jkfn.2012.41.6.766 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Food Science and Nutrition, v.41, no.6, pp 766 - 773 | - |
dc.identifier.kciid | ART001670245 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84929395673 | - |
dc.citation.endPage | 773 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 766 | - |
dc.citation.title | Journal of the Korean Society of Food Science and Nutrition | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Blood glucose | - |
dc.subject.keywordAuthor | Cudrania tricuspidata | - |
dc.subject.keywordAuthor | Diabetic rats | - |
dc.subject.keywordAuthor | Mulberry leaves | - |
dc.subject.keywordAuthor | Triglyceride | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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