Topical formulation of retinyl retinoate employing nanostructured lipid carriers
DC Field | Value | Language |
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dc.contributor.author | Lee, S.G. | - |
dc.contributor.author | Jeong, J.H. | - |
dc.contributor.author | Kim, S.R. | - |
dc.contributor.author | Lee, K.M. | - |
dc.contributor.author | Ahn, B.K. | - |
dc.contributor.author | Kang, M.H. | - |
dc.contributor.author | Choi, Y.W. | - |
dc.date.available | 2019-05-29T09:35:17Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20922 | - |
dc.description.abstract | Topical formulation of retinyl retinoate (RR) was developed with nanostructured lipid carriers (NLCs), composed of Compritol or Precirol as a solid lipid, canola oil as an oil, and Tween 80 as a surfactant. Hot high pressure homogenization method was efficiently employed to yield a homogenous nanodispersion in the size range of 230-300 nm with PDI values of <0. 2, regardless of lipid selection. Precirol-based NLC (P-NLC) showed higher drug entrapment than that of Compritol-based NLC (C-NLC): RR encapsulation efficiency (%) of P- and C-NLC was 97. 8 and 93. 8 in average, respectively; drug loading (mg RR/g lipid) was 89. 6 and 83. 3 in average, respectively. Processing condition at relatively low temperature of 60 °C was a key factor for maintaining RR stability. Drug release of P-NLC was greater than that of C-NLC, even though both NLCs revealed controlled release pattern. Therefore, P-NLC system was considered as a suitable vehicle for topical drug delivery, especially for heat-labile ingredient like RR. © 2012 The Korean Society of Pharmaceutical Sciences and Technology. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Topical formulation of retinyl retinoate employing nanostructured lipid carriers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s40005-012-0036-1 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Investigation, v.42, no.5, pp 243 - 250 | - |
dc.identifier.kciid | ART001705594 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84873719899 | - |
dc.citation.endPage | 250 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 243 | - |
dc.citation.title | Journal of Pharmaceutical Investigation | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | High pressure homogenization | - |
dc.subject.keywordAuthor | Nanostructured lipid carriers | - |
dc.subject.keywordAuthor | Processing stability | - |
dc.subject.keywordAuthor | Retinyl retinoate | - |
dc.subject.keywordAuthor | Topical delivery | - |
dc.subject.keywordPlus | canola oil | - |
dc.subject.keywordPlus | glycerol behenate | - |
dc.subject.keywordPlus | glycerol palmitostearate | - |
dc.subject.keywordPlus | nanocarrier | - |
dc.subject.keywordPlus | polysorbate 80 | - |
dc.subject.keywordPlus | retinoid | - |
dc.subject.keywordPlus | retinyl retinoate | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | water | - |
dc.subject.keywordPlus | accuracy | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | differential scanning calorimetry | - |
dc.subject.keywordPlus | drug delivery system | - |
dc.subject.keywordPlus | drug release | - |
dc.subject.keywordPlus | encapsulation | - |
dc.subject.keywordPlus | high performance liquid chromatography | - |
dc.subject.keywordPlus | nanoemulsion | - |
dc.subject.keywordPlus | particle size | - |
dc.subject.keywordPlus | photon correlation spectroscopy | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | solubility | - |
dc.subject.keywordPlus | toical delivery system | - |
dc.subject.keywordPlus | zeta potential | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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