BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
DC Field | Value | Language |
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dc.contributor.author | Lee, Jaehwi | - |
dc.contributor.author | Rhee, Man Hee | - |
dc.contributor.author | Kim, Eunji | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.available | 2019-05-29T09:36:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.issn | 1466-1861 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20968 | - |
dc.description.abstract | BAY 11-7082 (BAY) is an inhibitor of kappa B kinase (IKK) that has pharmacological activities that include anticancer, neuroprotective, and anti-inflammatory effects. In this study, BAY-pharmacological target pathways were further characterized to determine how this compound simultaneously suppresses various responses. Primary and cancerous (RAW264.7 cells) macrophages were activated by lipopolysaccharide, a ligand of toll-like receptor 4. As reported previously, BAY strongly suppressed the production of nitric oxide, prostaglandin E-2, and tumor necrosis factor-alpha and reduced the translocation of p65, major subunit of nuclear factor-kappa B, and its upstream signaling events such as phosphorylation of I kappa B alpha, IKK, and Akt. In addition, BAY also suppressed the translocation and activation of activator protein-1, interferon regulatory factor-3, and signal transducer and activator of transcription-1 by inhibiting the phosphorylation or activation of extracellular signal-related kinase, p38, TANK-binding protein, and Janus kinase-2. These data strongly suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs with multiple targets in inflammatory responses. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.title | BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2012/416036 | - |
dc.identifier.bibliographicCitation | MEDIATORS OF INFLAMMATION, v.2012 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000306054800001 | - |
dc.identifier.scopusid | 2-s2.0-84863690805 | - |
dc.citation.title | MEDIATORS OF INFLAMMATION | - |
dc.citation.volume | 2012 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | GINSENG | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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