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Cited 45 time in webofscience Cited 53 time in scopus
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BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets

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dc.contributor.authorLee, Jaehwi-
dc.contributor.authorRhee, Man Hee-
dc.contributor.authorKim, Eunji-
dc.contributor.authorCho, Jae Youl-
dc.date.available2019-05-29T09:36:29Z-
dc.date.issued2012-
dc.identifier.issn0962-9351-
dc.identifier.issn1466-1861-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20968-
dc.description.abstractBAY 11-7082 (BAY) is an inhibitor of kappa B kinase (IKK) that has pharmacological activities that include anticancer, neuroprotective, and anti-inflammatory effects. In this study, BAY-pharmacological target pathways were further characterized to determine how this compound simultaneously suppresses various responses. Primary and cancerous (RAW264.7 cells) macrophages were activated by lipopolysaccharide, a ligand of toll-like receptor 4. As reported previously, BAY strongly suppressed the production of nitric oxide, prostaglandin E-2, and tumor necrosis factor-alpha and reduced the translocation of p65, major subunit of nuclear factor-kappa B, and its upstream signaling events such as phosphorylation of I kappa B alpha, IKK, and Akt. In addition, BAY also suppressed the translocation and activation of activator protein-1, interferon regulatory factor-3, and signal transducer and activator of transcription-1 by inhibiting the phosphorylation or activation of extracellular signal-related kinase, p38, TANK-binding protein, and Janus kinase-2. These data strongly suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs with multiple targets in inflammatory responses.-
dc.language영어-
dc.language.isoENG-
dc.publisherHINDAWI PUBLISHING CORPORATION-
dc.titleBAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets-
dc.typeArticle-
dc.identifier.doi10.1155/2012/416036-
dc.identifier.bibliographicCitationMEDIATORS OF INFLAMMATION, v.2012-
dc.description.isOpenAccessN-
dc.identifier.wosid000306054800001-
dc.identifier.scopusid2-s2.0-84863690805-
dc.citation.titleMEDIATORS OF INFLAMMATION-
dc.citation.volume2012-
dc.type.docTypeArticle-
dc.publisher.location미국-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusRHEUMATOID-ARTHRITIS-
dc.subject.keywordPlusPHOSPHATIDYLINOSITOL 3-KINASE-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusGINSENG-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusINFLAMMATION-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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