IL-1 beta Induction and IL-6 Suppression Are Associated with Aggravated Neuronal Damage in a Lipopolysaccharide-Pretreated Kainic Acid-Induced Rat Pup Seizure Model
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung-Hyun | - |
dc.contributor.author | Kim, Bong-Je | - |
dc.contributor.author | Kim, Yong Bum | - |
dc.contributor.author | Chung, Pil-Wook | - |
dc.contributor.author | Moon, Heui-Soo | - |
dc.contributor.author | Suh, Bum Chun | - |
dc.contributor.author | Yoon, Won Tae | - |
dc.contributor.author | Jin, Dong-Kwan | - |
dc.contributor.author | Park, Yong Shik | - |
dc.contributor.author | Lee, Yong-Taek | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.date.available | 2019-05-29T09:36:36Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1021-7401 | - |
dc.identifier.issn | 1423-0216 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20974 | - |
dc.description.abstract | Objectives: Reportedly, hippocampal neuronal degeneration by kainic acid (KA)-induced seizures in rats <14 days old was enhanced by lipopolysaccharide (LPS). This study was to test the hypothesis that cytokines such as interleukin (IL)-1 beta, IL-6 and tumor necrosis factor-alpha are associated with aggravated neuronal damage. Materials and Methods: Sixty male Sprague-Dawley, 14-day-old rats were used. Experiments were conducted in saline, LPS + saline, saline + KA and LPS + KA groups. Intraperitoneal LPS injections (0.04 mg/kg) were administered 3 h prior to KA injection (3 mg/kg). Results: The LPS + KA group showed a tendency toward shorter latency to seizure onset (p = 0.086) and significantly longer seizure duration (p < 0.05) compared with the KA group. Induction of the proconvulsant cytokine IL-1 beta in rat pup brains was significantly greater in the LPS + KA group compared to the KA group (38.8 +/- 5.5 vs. 9.2 +/- 1.0 pg/mu g; p < 0.05); however, IL-6 levels were higher in the KA group than in the LPS + KA group (108.7 +/- 6.8 vs. 60.9 +/- 4.7 pg/mu g; p < 0.05). The difference in tumor necrosis factor-alpha between the LPS + KA group and the KA group was insignificant (12.1 +/- 0.6 vs. 10.9 +/- 2.3 pg/mu g; p = 0.64). Conclusions: Our results showed an increase in the proconvulsant cytokine IL-beta and a decrease in a potentially neuroprotective cytokine, IL-6, in rat pups treated with LPS + KA. These results warrant further investigation into the possible role of IL-1 beta induction and IL-6 suppression in LPS-promoted neuronal damage. Copyright (C) 2012 S. Karger AG, Basel | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | IL-1 beta Induction and IL-6 Suppression Are Associated with Aggravated Neuronal Damage in a Lipopolysaccharide-Pretreated Kainic Acid-Induced Rat Pup Seizure Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000339579 | - |
dc.identifier.bibliographicCitation | NEUROIMMUNOMODULATION, v.19, no.5, pp 319 - 325 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000306887500007 | - |
dc.identifier.scopusid | 2-s2.0-84863765314 | - |
dc.citation.endPage | 325 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 319 | - |
dc.citation.title | NEUROIMMUNOMODULATION | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Febrile seizure | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | Kainic acid | - |
dc.subject.keywordAuthor | Interleukin-1 beta | - |
dc.subject.keywordAuthor | Interleukin-6 | - |
dc.subject.keywordPlus | TEMPORAL-LOBE EPILEPSY | - |
dc.subject.keywordPlus | FEBRILE CONVULSIONS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | HIPPOCAMPAL MALFORMATION | - |
dc.subject.keywordPlus | STATUS EPILEPTICUS | - |
dc.subject.keywordPlus | IMMATURE RAT | - |
dc.subject.keywordPlus | INCREASE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | EPILEPTOGENESIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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