Functional analysis of a Hansenula polymorpha MNN2-2 homologue encoding a putative UDP-N-acetylglucosamine transporter localized in the endoplasmic reticulum
DC Field | Value | Language |
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dc.contributor.author | Park, Jeong-Nam | - |
dc.contributor.author | Choo, Jinho | - |
dc.contributor.author | Kang, Hyun Ah | - |
dc.date.available | 2019-05-29T09:39:41Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.issn | 1976-3794 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21077 | - |
dc.description.abstract | The Kluyveromyces lactis UDP-GlcNAc transporter (KlMnn2-2p) is responsible for the biosynthesis of N-glycans containing N-acetylglucosamine. A putative gene of Hansenula polymorpha encoding a KlMnn2-2p homologue, HpMNN2-2, was identified and investigated for its function. The deletion mutant strain of HpMNN2-2 (Hpmnn2-2 Delta) showed increased sensitivity to geneticin, hygromycin B, and tunicamycin. However, the Hpmnn2-2 Delta strain exhibited increased resistance to Calcofluor white, an inhibitor of chitin biosynthesis, along with a reduced chitin content. The localization of HpMnn2-2p at the endoplasmic reticulum-enriched membrane, different from the Golgi localization of a K. lactis homologue, further supports the involvement of HpMnn2-2p in cell wall chitin biosynthesis. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.title | Functional analysis of a Hansenula polymorpha MNN2-2 homologue encoding a putative UDP-N-acetylglucosamine transporter localized in the endoplasmic reticulum | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12275-011-1520-4 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.49, no.6, pp 1012 - 1017 | - |
dc.identifier.kciid | ART001611866 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000298602600019 | - |
dc.identifier.scopusid | 2-s2.0-84555206966 | - |
dc.citation.endPage | 1017 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1012 | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 49 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hansenula polymorpha | - |
dc.subject.keywordAuthor | UDP-GlcNAc transporter | - |
dc.subject.keywordAuthor | endoplasmic reticulum | - |
dc.subject.keywordAuthor | chitin | - |
dc.subject.keywordPlus | NUCLEOTIDE SUGAR TRANSPORTERS | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | CELL-WALL | - |
dc.subject.keywordPlus | CHITIN SYNTHESIS | - |
dc.subject.keywordPlus | KLUYVEROMYCES-LACTIS | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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