In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Hoon | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.available | 2019-03-07T04:40:06Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.issn | 2212-5469 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/2109 | - |
dc.description.abstract | The aim of this study was to prepare inclusion nanocomplexes of hyaluronic acid-beta-cyclodextrin and simvastatin (HA-beta-CD/SIM) and evaluate in vitro anti-inflammation effects on lipopolysaccharide (LPS)-activated synoviocytes and chondrogenic differentiation effects on rat adipose-derived stem cells (rADSCs). The beta-CD moieties in HA-beta-CD could incorporate SIM to form HA-beta-CD/SIM nanocomplexes with diameters of 297-350 nm. HA-beta-CD/SIM resulted in long-term release of SIM from the nanocomplexes for up to 63 days in a sustained manner. In vitro studies revealed that HA-beta-CD/SIM nanocomplexes were able to effectively and dose-dependently suppress the mRNA expression levels of pro-inflammatory markers such as matrix metallopeptidase-3 (MMP-3), MMP-13, cyclooxygenase-2 (COX-2), a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5), interleukin-6 (IL-6), and tumor necrosis factor (TNF-alpha) in LPS-stimulated synoviocytes. HA-beta-CD/SIM-treated rADSCs significantly and dose-dependently enhanced mRNA expressions of aggrecan, collagen type II (COL2A1), and collagen type X (COL10A1), implying that HA-beta-CD/SIM greatly induced the chondrogenic differentiation of rADSCs. Conclusively, HA-beta-CD/SIM nanocomplexes will be a promising therapeutic material to alleviate inflammation as well as promote chondrogenesis. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.title | In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13770-018-0119-9 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.15, no.3, pp 263 - 274 | - |
dc.identifier.kciid | ART002351689 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000433142400002 | - |
dc.identifier.scopusid | 2-s2.0-85047522191 | - |
dc.citation.endPage | 274 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 263 | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hyaluronic acid-beta-cyclodextrin | - |
dc.subject.keywordAuthor | Simvastatin | - |
dc.subject.keywordAuthor | Chondrogenesis | - |
dc.subject.keywordAuthor | Adipose-derived stem cells | - |
dc.subject.keywordPlus | COA REDUCTASE INHIBITORS | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | ARTICULAR CHONDROCYTES | - |
dc.subject.keywordPlus | KNEE OSTEOARTHRITIS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | SECRETION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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