Asymmetry of Motor Unit Number Estimate and Its Rate of Decline in Patients With Amyotrophic Lateral Sclerosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Suk-Won | - |
dc.contributor.author | Kim, Jee-Eun | - |
dc.contributor.author | Sung, Jung-Joon | - |
dc.contributor.author | Lee, Kwang-Woo | - |
dc.contributor.author | Hong, Yoon-Ho | - |
dc.date.available | 2019-05-29T11:33:59Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0736-0258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21204 | - |
dc.description.abstract | This study was performed to investigate the asymmetry of motor unit number estimate (MUNE) and its longitudinal course in patients with amyotrophic lateral sclerosis. A modified statistical MUNE was performed at the hypothenar muscles bilaterally in a total of 135 patients, and 18 of these patients underwent a follow-up study. The degree of asymmetry varied considerably among those patients whose average MUNE of both sides was moderately reduced, whereas it tended to be low in those whose average MUNE was either severely reduced or close to normal. The rate of motor unit loss was also asymmetric, and two distinct patterns were identified. In patients whose MUNE was greater than 30 in both sides (n = 7), the rate of motor unit loss tended to be greater in the initially more affected side compared with the contralateral one, yielding the so-called lead phenomenon. In contrast, the other patients (n = 11) tended to show the opposite pattern of "catch-up," that is, MUNE declined faster in the initially less affected side compared with the contralateral one. This study shows that not only the MUNE but also the rate of motor unit loss are frequently asymmetric in amyotrophic lateral sclerosis patients. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Asymmetry of Motor Unit Number Estimate and Its Rate of Decline in Patients With Amyotrophic Lateral Sclerosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/WNP.0b013e318231c9e0 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROPHYSIOLOGY, v.28, no.5, pp 528 - 532 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000295409100016 | - |
dc.identifier.scopusid | 2-s2.0-80053618334 | - |
dc.citation.endPage | 532 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 528 | - |
dc.citation.title | JOURNAL OF CLINICAL NEUROPHYSIOLOGY | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Motor unit number estimation | - |
dc.subject.keywordAuthor | Amyotrophic lateral sclerosis | - |
dc.subject.keywordAuthor | Asymmetry | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | MUTATION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.