Guanylate Cyclase Activator YC-1 Enhances TRAIL-Induced Apoptosis in Human Epithelial Ovarian Carcinoma Cells via Activation of Apoptosis-Related Proteins
DC Field | Value | Language |
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dc.contributor.author | Lee, Chung S. | - |
dc.contributor.author | Kim, Yun J. | - |
dc.contributor.author | Kim, Wonyong | - |
dc.contributor.author | Myung, Soon C. | - |
dc.date.available | 2019-05-29T11:34:44Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.issn | 1742-7843 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21226 | - |
dc.description.abstract | To assess the ability of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) to promote apoptosis, we investigated the effect of YC-1 on tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in the human epithelial ovarian carcinoma cell lines. In OVCAR-3 and SK-OV-3 cell lines, we examined the stimulatory effect of YC-1 on TRAIL-induced apoptosis by monitoring cell death, nuclear damage, changes in apoptosis-related protein levels, activation of caspases and changes in the mitochondrial transmembrane potential. TRAIL induced a decrease in Bid, Bcl-2 and Bcl-xL protein levels, increase in cleaved Bid and Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3) and an increase in the tumour suppressor p53 levels. YC-1 enhanced TRAIL-induced apoptosis-related protein activation, nuclear damage and cell death. Results from this study suggest that YC-1 may enhance the apoptotic effect of TRAIL on ovarian carcinoma cell lines by increasing the activation of the caspase-8- and Bid-dependent pathways and the mitochondria-mediated apoptotic pathway, leading to caspase activation. YC-1 may confer a benefit in TRAIL treatment of epithelial ovarian adenocarcinoma. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Guanylate Cyclase Activator YC-1 Enhances TRAIL-Induced Apoptosis in Human Epithelial Ovarian Carcinoma Cells via Activation of Apoptosis-Related Proteins | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1742-7843.2011.00717.x | - |
dc.identifier.bibliographicCitation | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v.109, no.4, pp 283 - 291 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000294900200010 | - |
dc.identifier.scopusid | 2-s2.0-80052655490 | - |
dc.citation.endPage | 291 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 283 | - |
dc.citation.title | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | - |
dc.citation.volume | 109 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | PANCREATIC-CANCER CELLS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | MEDIATED APOPTOSIS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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