Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline heal Longitudinal Smooth Muscle
DC Field | Value | Language |
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dc.contributor.author | Wang, YiYi | - |
dc.contributor.author | Park, Sun Young | - |
dc.contributor.author | Oh, Kyung Hoon | - |
dc.contributor.author | Min, Youngsil | - |
dc.contributor.author | Lee, Yun-Jeong | - |
dc.contributor.author | Lee, Seok-Yong | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.date.available | 2019-05-29T11:35:14Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21240 | - |
dc.description.abstract | A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes. In the present study, we investigated the pharmacological characterization of the 5-HT-induced contractile response in longitudinal smooth muscle isolated from the feline ileum. Addition of 5-HT into muscle chambers enhanced the basal tone and spontaneous activity in a concentration-dependent manner. The neurotoxin tetrodotoxin did not alter the 5-HT-induced contraction of the longitudinal muscles. Neither atropine nor guanethidine affected the contraction. The 5-HT agonists, 5-methylserotonin hydrochloride and mosapride, also evoked concentration-dependent contractions. The 5-HT-induced contraction was enhanced by the 5HT(2) receptor antagonist ketanserin and the 5-HT, receptor antagonist ondansetron but was inhibited by the 5-HT(1) receptor antagonist methysergide and 5-HT(4) receptor antagonist GR113808. These results indicate that 5-HT(1) and 5-HT(4) receptors may mediate the contraction of the 5-HT-induced response and 5-HT(2) and 5-HT(3) receptors may mediate 5-HT-induced relaxation in feline ileal longitudinal smooth muscles. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline heal Longitudinal Smooth Muscle | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2011.15.5.267 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.15, no.5, pp 267 - 272 | - |
dc.identifier.kciid | ART001599420 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000296954900003 | - |
dc.identifier.scopusid | 2-s2.0-81455138269 | - |
dc.citation.endPage | 272 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 267 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Ileum | - |
dc.subject.keywordAuthor | Longitudinal smooth muscle | - |
dc.subject.keywordAuthor | 5-HT | - |
dc.subject.keywordAuthor | Contraction | - |
dc.subject.keywordAuthor | Relaxation | - |
dc.subject.keywordPlus | IRRITABLE-BOWEL-SYNDROME | - |
dc.subject.keywordPlus | GUINEA-PIG ILEUM | - |
dc.subject.keywordPlus | PHARMACOLOGICAL CHARACTERIZATION | - |
dc.subject.keywordPlus | MEDIATING CONTRACTION | - |
dc.subject.keywordPlus | INTERSTITIAL-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PLASMA 5-HYDROXYTRYPTAMINE | - |
dc.subject.keywordPlus | GASTROINTESTINAL-TRACT | - |
dc.subject.keywordPlus | CIRCULAR MUSCLE | - |
dc.subject.keywordPlus | 5-HT RECEPTORS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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