Anti-obesity Effect of Carbon Dioxide Supercritical Fluid Extracts of Panax Ginseng C. A. Meyer
DC Field | Value | Language |
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dc.contributor.author | Woo, Hyun-Chul | - |
dc.contributor.author | Shin, Bok-Kyu | - |
dc.contributor.author | Cho, Inja | - |
dc.contributor.author | Koo, Hana | - |
dc.contributor.author | Kim, Mihyang | - |
dc.contributor.author | Han, Jaehong | - |
dc.date.available | 2019-05-29T11:35:24Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 1738-2203 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21246 | - |
dc.description.abstract | The root of Korean ginseng, Panax ginseng C. A. Meyer, has been known worldwide as a panacea for many centuries. Contradictory weight gain and loss effects in Korean ginseng led to the adoption of supercritical carbon dioxide extraction to assure the quality of food-grade anti-obesity ginseng products. Among different extraction conditions of CO, pressure (200 and 300 bars) and temperature (40, 50, and 60 degrees C), the highest extraction yield of 0.66% was obtained with 300 bars at 40 degrees C. To test anti-obesity effect, each supercritical fluid extract (SFE) was supplemented to the high-fat diet of male obese-prone C57BL/6J strain mice. All carbon dioxide SFEs of ginseng showed significant weight-loss effects in the tested mice. The average weights of normal and high fat diet mice were 28.7 +/- 2.0 and 35.0 +/- 1.6 g, respectively, after 10 weeks. Average weights of mice on SFE-supplemented high fat diets were between 24.5 +/- 1.4 and 25.9 +/- 13 g. SFEs obtained at 50 degrees C, and at both 200 and 300 bars, showed the most profound anti-obesity effect. Both SFEs showed 15 and similar to 30% weight loss for the normal and high-fat diet mice, respectively. The major component of the SFE was analyzed as polyacetylene compounds, and panaxydol and panaxynol were identified as major polyacetylene compounds. However, the anti-obesity effect of the ginseng SFEs was not correlated with contents of these two polyacetylene compounds in SFEs. No side-effects of ginseng SFEs were observed, and the anti-obesity effect was reversible. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY | - |
dc.title | Anti-obesity Effect of Carbon Dioxide Supercritical Fluid Extracts of Panax Ginseng C. A. Meyer | - |
dc.type | Article | - |
dc.identifier.doi | 10.3839/jksabc.2011.111 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.54, no.5, pp 738 - 743 | - |
dc.identifier.kciid | ART001600773 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000297384800011 | - |
dc.identifier.scopusid | 2-s2.0-83355164833 | - |
dc.citation.endPage | 743 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 738 | - |
dc.citation.title | JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 54 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | carbon dioxide | - |
dc.subject.keywordAuthor | ginseng | - |
dc.subject.keywordAuthor | polyacetylene | - |
dc.subject.keywordAuthor | supercritical fluid extraction | - |
dc.subject.keywordPlus | RADIX GINSENG | - |
dc.subject.keywordPlus | POLYACETYLENES | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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