Venlafaxine inhibits the development and differentiation of dendritic cells through the regulation of p-glycoprotein
DC Field | Value | Language |
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dc.contributor.author | Lee, Jun Sik | - |
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Lee, Chang-Min | - |
dc.contributor.author | Noh, Kyung Tae | - |
dc.contributor.author | Park, Jin Wook | - |
dc.contributor.author | Son, Kwang Hee | - |
dc.contributor.author | Heo, Deok Rim | - |
dc.contributor.author | Shin, Yong Kyoo | - |
dc.contributor.author | Kim, Daejin | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.date.available | 2019-05-29T11:36:34Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21292 | - |
dc.description.abstract | Dendritic cells (DC) are professional antigen-presenting cells that have the ability to detect infectious materials; antigens to T lymphocytes, and serve as a bridge between innate and adaptive immunities. DC express the ATP-binding cassette transporters P-glycoprotein (P-gp). P-gp is a 170-kDa transmembrane protein encoded by the mdr-1 gene, a member of highly conserved superfamily of ATP-binding cassette transport proteins. Functionally, P-gp transporters have been described to be required for efficient DC and T cell migration. We report for the first time, at the best of our knowledge. P-gp is also required for DC development and differentiation in mouse bone marrow-derived DC. In this study, we found that an mdr-1 gene and P-gp protein level was increased during DC development and LPS-induced maturation. Moreover, the activity of P-gp was increased LPS-induced DC maturation. Next, we have attempted to determine whether the modulation of P-gp regulates surface molecules expression and cytokine production in DC. Specifically, down-regulation of P-gp by Venlafaxine (VEX) inhibits the differentiation of DC and cytokine production, such as IL-1, IL-10, and IL-12 during DC maturation. Moreover, the P-gp-decreased DC by VLX was displayed impaired induction of T cell polarizations, proliferation, and cytokine production, including IFN-gamma, IL-4, and IL-2. Taken together, these findings also broaden current perspective concerning our understanding of the immunopharmacological functions of VLX and the development of therapeutic adjuvants for the treatment of DC-related acute and chronic diseases. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Venlafaxine inhibits the development and differentiation of dendritic cells through the regulation of p-glycoprotein | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.intimp.2011.04.019 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.11, no.9, pp 1348 - 1357 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000294877600029 | - |
dc.identifier.scopusid | 2-s2.0-80051903575 | - |
dc.citation.endPage | 1357 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1348 | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | P-glycoprotein | - |
dc.subject.keywordAuthor | Development | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | ABC TRANSPORTER | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | CYCLOSPORINE-A | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | VERAPAMIL | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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