Effect of Initial Ziprasidone Dose on Treatment Outcome of Korean Patients with Acute Manic or Mixed Episodes
- Authors
- Woo, Young Sup; Bahk, Won-Myong; Jo, Soo Hyun; Yoon, Bo-Hyun; Lee, Jung Goo; Kim, Won; Jeong, Jong-Hyun; Seo, Jeong Seok; Min, Kyung Joon; Jon, Duk-In
- Issue Date
- Sep-2011
- Publisher
- KOREAN NEUROPSYCHIATRIC ASSOC
- Keywords
- Bipolar disorder; Divalproex; Initial dose; Manic episode; Ziprasidone
- Citation
- PSYCHIATRY INVESTIGATION, v.8, no.3, pp 207 - 213
- Pages
- 7
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 8
- Number
- 3
- Start Page
- 207
- End Page
- 213
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21301
- DOI
- 10.4306/pi.2011.8.3.207
- ISSN
- 1738-3684
1976-3026
- Abstract
- Objective We investigated the efficacy and tolerability of ziprasidone combined with divalproex to determine the relationship between the initial dose of ziprasidone and the treatment effect among Korean patients with acute bipolar manic or mixed disorders. Methods This study was a 6-week, open-label, prospective investigation of Korean patients with an acute manic or mixed episode of bipolar disorder. Sixty-five patients were recruited. The patients were categorized based on the initial dose of ziprasidone as follows: low (2079 mg/day) and standard (80 mg/day). Ziprasidone was given in combination with divalproex in flexible doses, according to the clinical response and tolerability. Results The response and remission rates were significantly higher in the standard-dose group than the low-dose group. The combination of ziprasidone and divalproex was well-tolerated and adverse events were mostly mild with no statistically significant increase in body weight. Conclusion The results of this study showed that a standard starting dose of ziprasidone in combination with divalproex for bipolar disorder is more effective than a low starting dose. Psychiatry Investig 2011;8:207-213
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21301)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.