Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug
DC Field | Value | Language |
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dc.contributor.author | Huyen Thi Thanh Tran | - |
dc.contributor.author | Park, Jun Bom | - |
dc.contributor.author | Hong, Ki-Hyuk | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Han, Hyo-Kyung | - |
dc.contributor.author | Lee, Jaehwi | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Lee, Beom-Jin | - |
dc.date.available | 2019-05-29T11:37:31Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21328 | - |
dc.description.abstract | Sustained release (SR) tablets containing solid dispersions (SD) granules of a poorly water-soluble drug were prepared to investigate the controlled pH-independent release of the drug. Losartan potassium (LST), an anti-hypertensive agent was chosen as a model drug because of its pH-dependent solubility and short elimination half-life. Poloxamer 188 was used as an SD carrier. A free-flowing SD granule was prepared by adsorbing the melt of the drug and poloxamer 188 onto the surface of an adsorbent. Aerosil 300 (fumed silicon dioxide), followed by direct compression with polyethylene oxide (PEO, 5 x 10(6)) to obtain an SD-loaded SR (SD-SR) matrix tablet. Differential scanning calorimetry (DSC) and powder Xray diffraction (PXRD) revealed partially amorphous structures of the drug in the SD granules. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) images indicated adsorption of SD granules onto the surface of the adsorbent. The SD granules dissolved completely within 10 min, a dissolution rate much higher than that of pure LST. Moreover, pH-independent sustained release of LST from the SD-SR tablet was achieved for 2 h in gastric fluid (pH 1.2) and for 10 h in intestinal fluid (pH 6.8). A combination of SD techniques using surface adsorption and SR concepts is a promising approach to control the release rate of poorly water-soluble drugs in a pH-independent manner. (C) 2011 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijpharm.2011.05.052 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.415, no.1-2, pp 83 - 88 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000293304900011 | - |
dc.identifier.scopusid | 2-s2.0-79960200912 | - |
dc.citation.endPage | 88 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 83 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 415 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Solid dispersion granules | - |
dc.subject.keywordAuthor | Surface adsorption | - |
dc.subject.keywordAuthor | Sustained release tablet | - |
dc.subject.keywordAuthor | pH-independent release | - |
dc.subject.keywordAuthor | EDS imaging | - |
dc.subject.keywordPlus | POLYETHYLENE OXIDES PEOS | - |
dc.subject.keywordPlus | MATRIX TABLETS | - |
dc.subject.keywordPlus | LOSARTAN POTASSIUM | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | DISSOLUTION | - |
dc.subject.keywordPlus | HYDROXYPROPYLMETHYLCELLULOSE | - |
dc.subject.keywordPlus | NILVADIPINE | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | DESIGN | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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