Enhancement of Cardiac Myoblast Responses onto Electrospun PLCL Fibrous Matrices Coated with Polydopamine for Gelatin Immobilization
DC Field | Value | Language |
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dc.contributor.author | Shin, Young Min | - |
dc.contributor.author | Park, Hansoo | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.date.available | 2019-05-29T11:39:02Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.issn | 2092-7673 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21376 | - |
dc.description.abstract | A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanical properties. In this study, dopamine was used as a bridge molecule to immobilize gelatin on the poly(L-lactide-co-epsilon-caprolactone) (PLCL) fibrous matrices, which may then be used as a cell delivery carrier. The PLCL fibrous matrices coated with polydopamine by dipping (D-PLCL) can subsequently immobilize gelatin (GD-PLCL). The D-PLCL matrices showed minimal changes in the mechanical properties with a tensile strain of 251.0 +/- 33.4% and 247.8 +/- 32.1% before and after the coating process, respectively. The cellular activities on the fibrous matrices increased in the order of PLCL<G-PLCL<D-PLCL<GD-PLCL; the H9c2 myoblasts on the GD-PLCL matrices showed approximately two-times higher adhesion and spreading than those on the PLCL matrices, and the proliferation was significantly greater on the GD-PLCL matrices than on the other matrices. Therefore, polydopamine can effectively immobilize the bioactive functional groups on the surface of electrospun fibrous matrices for the development of a tissue specific cell delivery carrier. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Enhancement of Cardiac Myoblast Responses onto Electrospun PLCL Fibrous Matrices Coated with Polydopamine for Gelatin Immobilization | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13233-011-0815-y | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.19, no.8, pp 835 - 842 | - |
dc.identifier.kciid | ART001571974 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000293962500012 | - |
dc.identifier.scopusid | 2-s2.0-80052646509 | - |
dc.citation.endPage | 842 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 835 | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | surface modification | - |
dc.subject.keywordAuthor | polydopamine | - |
dc.subject.keywordAuthor | electrospinning | - |
dc.subject.keywordAuthor | gelatin | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | SURFACE MODIFICATION | - |
dc.subject.keywordPlus | MYOCARDIAL TISSUE | - |
dc.subject.keywordPlus | WOUNDED HEART | - |
dc.subject.keywordPlus | ACRYLIC-ACID | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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