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A transcription factor hijacking to regulate RAR alpha by using a chimeric molecule of retinoic acid and a DNA alkylator
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Min, Kyung Hoon | - |
| dc.contributor.author | Yun, Byoung-Gu | - |
| dc.contributor.author | Lee, Yoonsung | - |
| dc.contributor.author | Song, Jiho | - |
| dc.contributor.author | Ham, Won-Hoon | - |
| dc.contributor.author | Lee, YoungJoo | - |
| dc.contributor.author | Park, Hyun-Ju | - |
| dc.date.available | 2019-05-29T11:39:52Z | - |
| dc.date.issued | 2011-07 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21404 | - |
| dc.description.abstract | As a model compound for the transcription factor hijacking mechanism of action of DNA damaging agent that simultaneously bind to the nuclear receptor, we designed and synthesized a chimeric molecule, RA-mustard, which can bind with both retinoic acid receptor alpha (RAR alpha) and DNA. The interaction between RA-mustard with RAR alpha was confirmed by binding assay using RAR alpha-overexpressing cell extract. RA-mustard-modified DNA diminished the RAR alpha-dependent luciferase expression in the RAR alpha-abundant cells. (C) 2011 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | A transcription factor hijacking to regulate RAR alpha by using a chimeric molecule of retinoic acid and a DNA alkylator | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.bmcl.2011.05.062 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.14, pp 4248 - 4251 | - |
| dc.description.isOpenAccess | N | - |
| dc.identifier.wosid | 000292186400027 | - |
| dc.identifier.scopusid | 2-s2.0-79959876470 | - |
| dc.citation.endPage | 4251 | - |
| dc.citation.number | 14 | - |
| dc.citation.startPage | 4248 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 21 | - |
| dc.type.docType | Article | - |
| dc.publisher.location | 영국 | - |
| dc.subject.keywordAuthor | Transcription factor hijacking | - |
| dc.subject.keywordAuthor | Chimeric molecule | - |
| dc.subject.keywordAuthor | Chlorambucil | - |
| dc.subject.keywordAuthor | All-trans retinoic acid | - |
| dc.subject.keywordAuthor | Retinoic acid receptor alpha | - |
| dc.subject.keywordPlus | CANCER CELLS | - |
| dc.subject.keywordPlus | LIGAND | - |
| dc.subject.keywordPlus | EXPRESSION | - |
| dc.subject.keywordPlus | PROTEINS | - |
| dc.subject.keywordPlus | COMPLEX | - |
| dc.subject.keywordPlus | DESIGN | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
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