Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Oh, Young Taik | - |
dc.contributor.author | Lee, Kyung Soo | - |
dc.contributor.author | Yun, Jeong Min | - |
dc.contributor.author | Park, Byung Tae | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.available | 2019-05-29T13:35:28Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.issn | 2092-7673 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21573 | - |
dc.description.abstract | pH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs specifically to solid tumors or to acidosis-affected rheumatic joints. In this study, a poly(L-aspartic acid-graftimidazole)-block-poly(ethylene glycol) (P(Asp-g-Im)-PEG) block copolymer was synthesized as a pH sensitive nanocarrier targeting acidic pH environments. The polypeptide P(Asp), which was used as a backbone for the hydrophobic block, was synthesized by ring opening polymerization with N-carboxylanhydride (NCA) of beta-benzyl-aspartic acid. PEG was included as the hydrophilic block and the polymer was functionalized with imidazole groups to confer pH sensitivity. The prepared P(Asp-g-Im)-PEG is zwitterionic with a pI 6.5; 60% of the available carboxyl groups of P(Asp)-PEG were substituted by imidazole groups. Furthermore, the potentiometric titration curve of P(Asp-g-Im)-PEG demonstrated a broad buffer zone. The micelles prepared from P(Asp-g-Im)-PEG showed pH dependent critical micelle concentrations (CMC), particle sizes, zeta potentials, and morphologies. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13233-011-0502-z | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.19, no.5, pp 453 - 460 | - |
dc.identifier.kciid | ART001552960 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000290941800006 | - |
dc.identifier.scopusid | 2-s2.0-79960035017 | - |
dc.citation.endPage | 460 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 453 | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | pH sensitive | - |
dc.subject.keywordAuthor | micelle destabilization | - |
dc.subject.keywordAuthor | nanocarrier | - |
dc.subject.keywordAuthor | polyelectrolytes | - |
dc.subject.keywordAuthor | poly(aspartic acid-graft-imidazole) | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | BUFFERING CAPACITY | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | AQUEOUS-MEDIA | - |
dc.subject.keywordPlus | TUMOR PH | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.