Protective Effect of Chlorogenic Acid against A beta-Induced Neurotoxicity
- Authors
- Lee, Chan Woo; Won, Tae Joon; Kim, Hak Rim; Lee, Dongho; Hwang, Kwang Woo; Park, So-Young
- Issue Date
- 30-Apr-2011
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Chlorogenic acid; Beta-amyloid; Calcium influx; Apoptosis; PC12 cells
- Citation
- BIOMOLECULES & THERAPEUTICS, v.19, no.2, pp 181 - 186
- Pages
- 6
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 19
- Number
- 2
- Start Page
- 181
- End Page
- 186
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21592
- DOI
- 10.4062/biomolther.2011.19.2.181
- ISSN
- 1976-9148
2005-4483
- Abstract
- Beta-amyloid (A beta) is considered as one of the major causes of Alzheimer's disease. This study examined the neuroprotective effects of chlorogenic acid, a naturally occurring polyphenol which is distributed widely in plants, fruits and vegetables, against An-induced toxicity. A beta decreased significantly the viability of PC12 cells. This was accompanied by an increase in the intracellular calcium levels and cleaved caspase-3. In addition, A beta induced an increase in Bax, and a decrease in Bcl-2 compared to the controls. However, a pre-treatment with chlorogenic acid rescued the PC12 cells from A beta by attenuating the elevated intracellular calcium levels and reducing the levels of the apoptosis related proteins, including caspase-3, Bcl-2 and Bax. These results suggest that the protective effects of chlorogenic acid are, at least in parts, by attenuating the intracellular calcium influx and reducing apoptosis induced by A beta.
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