The chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis
DC Field | Value | Language |
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dc.contributor.author | Moon, Jeong Yong | - |
dc.contributor.author | Mosaddik, Ashik | - |
dc.contributor.author | Kim, Hana | - |
dc.contributor.author | Cho, Moonjae | - |
dc.contributor.author | Choi, Hyung-Kyoon | - |
dc.contributor.author | Kim, Young Suk | - |
dc.contributor.author | Cho, Somi Kim | - |
dc.date.available | 2019-05-29T13:38:27Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21671 | - |
dc.description.abstract | The antiproliferative activities of the chloroform fraction (CF) of guava (Psidium cattleianum Sabine) leaf extract were evaluated using several cancer cell lines. Maximum cytotoxicity was observed in SNU-16, a human gastric carcinoma cell line, at concentrations of 50-100 mu g/ml. Flow cytometric analysis demonstrated that CF treatment resulted in a marked accumulation of SNU-16 cells in the sub-G1 phase at concentrations of 100-200 mu g/ml. The induction of apoptosis in SNU-16 cells was confirmed by immunoblotting using antibodies against Bcl-2, Bax, poly (ADP-ribose) polymerase (PARP), caspase-8, and caspase-3. The major CF phytochemicals were identified as ferulic acid, genistein, 3', 4', 5' trimethoxy flavone, phlorizin, and oleanolic acid by high performance liquid chromatography coupled with a photo diode array and electrospray ionisation mass spectrometry (HPLC-PDA-ESI-MS). The results suggest that phytochemicals in the CF of guava (P. cattleianum) leaf extract induce apoptosis in SNU-16 cells. These findings may lead to new strategies for treating human gastric cancer. (C) 2010 Elsevier Ltd All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | The chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.foodchem.2010.09.007 | - |
dc.identifier.bibliographicCitation | FOOD CHEMISTRY, v.125, no.2, pp 369 - 375 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000284975200011 | - |
dc.identifier.scopusid | 2-s2.0-78049423971 | - |
dc.citation.endPage | 375 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 369 | - |
dc.citation.title | FOOD CHEMISTRY | - |
dc.citation.volume | 125 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Guava | - |
dc.subject.keywordAuthor | Caspase-3 | - |
dc.subject.keywordAuthor | High performance liquid chromatography coupled with photo diode array and electrospray ionisation mass spectrometry (HPLC-PDA-ESI-MS) | - |
dc.subject.keywordAuthor | Human gastric carcinoma cell | - |
dc.subject.keywordAuthor | Phytochemical | - |
dc.subject.keywordAuthor | SNU-16 | - |
dc.subject.keywordPlus | HUMAN LEUKEMIA-CELLS | - |
dc.subject.keywordPlus | LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | OLEANOLIC ACID | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENISTEIN | - |
dc.subject.keywordPlus | FLAVONES | - |
dc.subject.keywordPlus | GUAJAVA | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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