Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle
DC Field | Value | Language |
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dc.contributor.author | Yang, Hyun | - |
dc.contributor.author | Kim, Tae-Hee | - |
dc.contributor.author | Lee, Hae-Hyeog | - |
dc.contributor.author | Choi, Kyung-Chul | - |
dc.contributor.author | Hong, Yeon-Pyo | - |
dc.contributor.author | Leung, Peter C. K. | - |
dc.contributor.author | Jeung, Eui-Bae | - |
dc.date.available | 2019-05-29T13:38:37Z | - |
dc.date.issued | 2011-03-02 | - |
dc.identifier.issn | 1477-7827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21678 | - |
dc.description.abstract | Human endometrium resists embryo implantation except during the 'window of receptivity'. A change in endometrial gene expression is required for the development of receptivity. Uterine calbindin-D28k (CaBP-28k) is involved in the regulation of endometrial receptivity by intracellular Ca2+. Currently, this protein is known to be mainly expressed in brain, kidneys, and pancreas, but potential role(s) of CaBP-28k in the human uterus during the menstrual cycle remain to be clarified. Thus, in this study we demonstrated the expression of CaBP-28k in the human endometrium in distinct menstrual phases. During the human menstrual cycle, uterine expression levels of CaBP-28k mRNA and protein increased in the proliferative phase and fluctuated in these tissues, compared with that observed in other phases. We assessed the effects of two sex-steroid hormones, 17beta-estradiol (E2) and progesterone (P4), on the expression of CaBP-28k in Ishikawa cells. A significant increase in the expression of CaBP-28k mRNA was observed at the concentrations of E2 (10(-9 to -7) M). In addition, spatial expression of CaBP-28k protein was detected by immunohistochemistry. CaBP-28k was abundantly localized in the cytoplasm of the luminal and glandular epithelial cells during the proliferative phases (early-, mid-, late-) and early-secretory phase of menstrual cycle. Taken together, these results indicate that CaBP-28k, a uterine calcium binding protein, is abundantly expressed in the human endometrium, suggesting that uterine expression of CaBP-28k may be involved in reproductive function during the human menstrual cycle. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/1477-7827-9-28 | - |
dc.identifier.bibliographicCitation | REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, v.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000288271800001 | - |
dc.identifier.scopusid | 2-s2.0-79952083676 | - |
dc.citation.title | REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | CALCIUM-BINDING PROTEIN | - |
dc.subject.keywordPlus | VITAMIN-D DEFICIENCY | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | RAT UTERUS | - |
dc.subject.keywordPlus | EMBRYO IMPLANTATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | MOUSE UTERUS | - |
dc.subject.keywordPlus | 1,25-DIHYDROXYVITAMIN D3 | - |
dc.subject.keywordPlus | NA+/CA2+ EXCHANGERS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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