Catechin-7-O-beta-D-Glucopyranoside Scavenges Free Radicals and Protects Human B Lymphoma BJAB Cells on H2O2-mediated Oxidative Stress
DC Field | Value | Language |
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dc.contributor.author | Baek, Jin-A | - |
dc.contributor.author | Son, Young-Ok | - |
dc.contributor.author | Fang, Minghao | - |
dc.contributor.author | Lee, Young Jae | - |
dc.contributor.author | Cho, Hyoung-Kwon | - |
dc.contributor.author | Whang, Wan Kyunn | - |
dc.contributor.author | Lee, Jeong-Chae | - |
dc.date.available | 2019-05-30T00:14:31Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.issn | 2092-6456 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21775 | - |
dc.description.abstract | Catechin-7-O-beta-D-glucopyranoside (CA-G) was previously isolated from red bean (the seed of Phaseolus calcaratus cv. Roxburgh). This study examined the ability of CA-G to scavenge reactive oxygen species generated by cell-free systems and to protect cells from oxidative stress caused by hydrogen peroxide (H2O2). The mechanism by which CA-G exerts its antioxidant and anti-apoptotic action on H2O2-exposed cells was also investigated. CA-G treatment prevented H2O2-mediated apoptosis and inhibited the formation of single stand breaks in DNA in H2O2-exposed BJAB cells. CA-G suppressed mitochondrial stress and caspase activation caused by H2O2. Mechanistic experiments revealed that the antioxidant mechanism of CA-G on H2O2-mediated oxidative damage was due to the direct scavenging of hydroxyl radicals and/or to the chelation of metal ions that were used to produce hydroxyl radicals from H2O2 via the Fenton reaction. Collectively, these findings suggest beneficial roles of CA-G or CA-G-rich red bean on the protection from oxidative damage. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.title | Catechin-7-O-beta-D-Glucopyranoside Scavenges Free Radicals and Protects Human B Lymphoma BJAB Cells on H2O2-mediated Oxidative Stress | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10068-011-0021-x | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.1, pp 151 - 158 | - |
dc.identifier.kciid | ART001529979 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000287968300021 | - |
dc.identifier.scopusid | 2-s2.0-79959690806 | - |
dc.citation.endPage | 158 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 151 | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 20 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | catechin-7-O-beta-D-glucopyranoside | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | hydrogen peroxide | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | red bean | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | SUPEROXIDE DISMUTASE | - |
dc.subject.keywordPlus | ANTIOXIDANT PROPERTY | - |
dc.subject.keywordPlus | HYDROXYL RADICALS | - |
dc.subject.keywordPlus | MEDICINAL HERBS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | H2O2 | - |
dc.subject.keywordPlus | 2',7'-DICHLOROFLUORESCIN | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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