Effects of minocycline on Na+ currents in rat dorsal root ganglion neurons
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hoon | - |
dc.contributor.author | Kim, Hong Im | - |
dc.contributor.author | Kim, Jungho | - |
dc.contributor.author | Park, Mijung | - |
dc.contributor.author | Song, Jin-Ho | - |
dc.date.available | 2019-05-30T00:15:07Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.issn | 1872-6240 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21796 | - |
dc.description.abstract | Minocycline is an inhibitor of microglial activation and proliferation. Minocycline suppresses pain-related behaviors in many different pain states, which correlates closely with its inhibition of microglial activation and subsequent release of pro-inflammatory mediators in the spinal cord. Na+ channels in dorsal root ganglion (DRG) neurons are implicated in the generation of inflammatory and neuropathic pain. To elucidate a possible peripheral mechanism of minocycline analgesia, effects of minocycline on tetrodotoxin-sensitive and tetrodotoxin-resistant Na+ currents in rat DRG neurons were investigated. Minocycline potently inhibited both types of Na+ currents with IC50 values of 350 nM and 410 nM, respectively. The inhibition was accompanied by a depolarizing shift of the activation voltage. However, minocycline slowed the inactivation and speeded up the recovery from inactivation. These results suggest minocycline may exert analgesia peripherally thorough Na+ channel inhibition in the primary afferent neurons as well as centrally through microglial inhibition in the spinal cord. (C) 2010 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Effects of minocycline on Na+ currents in rat dorsal root ganglion neurons | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.brainres.2010.11.038 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH, v.1370, pp 34 - 42 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000287065900003 | - |
dc.identifier.scopusid | 2-s2.0-78651374512 | - |
dc.citation.endPage | 42 | - |
dc.citation.startPage | 34 | - |
dc.citation.title | BRAIN RESEARCH | - |
dc.citation.volume | 1370 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Dorsal root ganglion | - |
dc.subject.keywordAuthor | Minocycline | - |
dc.subject.keywordAuthor | Na+ current | - |
dc.subject.keywordAuthor | Tetracycline | - |
dc.subject.keywordAuthor | Tetrodotoxin-resistant | - |
dc.subject.keywordAuthor | Tetrodotoxin-sensitive | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | RESISTANT SODIUM-CHANNELS | - |
dc.subject.keywordPlus | SPINAL-CORD MICROGLIA | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | INFLAMMATORY PAIN | - |
dc.subject.keywordPlus | P38 MAPK | - |
dc.subject.keywordPlus | MECHANICAL ALLODYNIA | - |
dc.subject.keywordPlus | ALPHA-SUBUNIT | - |
dc.subject.keywordPlus | NA(V)1.7 PN1 | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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