Anti-asthmatic effects of phenylpropanoid glycosides from Clerodendron trichotomum leaves and Rumex gmelini herbes in conscious guinea-pigs challenged with aerosolized ovalbumin
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Yun | - |
dc.contributor.author | Lee, Jung Gun | - |
dc.contributor.author | Sim, Sang Soo | - |
dc.contributor.author | Whang, Wan-Kyunn | - |
dc.contributor.author | Kim, Chang Jong | - |
dc.date.available | 2019-05-30T00:15:12Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21800 | - |
dc.description.abstract | Clerodendron trichotomum leaves and Rumex aquatica herbs are used as a folk medicine for the treatment of inflammatory diseases, but their active ingredients are not known until now. We isolated caffeic acid and phenylpropanoid glycosides, 1-O-caffeoyl glycoside and acteoside [beta-(3',4'-dihydroxyphenyl) ethyl-O-alpha-L-rhamnopyranosyl(1 -> 3)-beta-D-(4-O-caffeoyl)-glucopyranoside] from their ethylacetate fractions, respectively, and evaluated their anti-asthmatic effects on the aerosolized ovalbumin (OA) challenge in the OA-sensitized guinea-pigs measuring the specific airway resistance (sRaw) during the immediate-phase response (IAR) and late-phase response (LAR), and also measured recruitment of leukocytes and chemical mediators on the bronchoalveolar lavage fluids (BALF) in LAR, as well as histopathological survey. Acteoside and 1-O-caffeoyl glycoside (25 mg/kg) significantly (P<0.05) inhibited sRaw by 32.14 and 26.79% in IAR, and by 55.88% and 52.94% in LAR, respectively, whereas caffeic acid (25 mg/kg) inhibited sRaw by 30.36% in IAR and 44.12% in LAR, compared to control, but with less effective than dexamethasone, disodium cromoglycate, and salbutamol, respectively. In addition, phenylpropanoid glycosides (25 mg/kg) significantly inhibited the recruitments of leukocytes, particularly neutrophils and eosinophils into lung, Furthermore, 1-O-caffeoyl glycoside, acteoside and caffeic acid significantly (P < 0.05) inhibited protein content at a dose of 25 mg/kg, and histamine content and PLA(2) activity at a dose of 50 mg/kg, in BALF. Acteoside had more active than caffeic acid and 1-O-caffeoyl glycoside. However, their anti-asthmatic effects were less than the reference drugs. These results indicated that caffeic acid and its glycosides (25 mg/kg) have anti-asthmatic effect as the same manner with dexamethasone and disodium cromoglycate. (C) 2010 Elsevier GmbH. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER GMBH, URBAN & FISCHER VERLAG | - |
dc.title | Anti-asthmatic effects of phenylpropanoid glycosides from Clerodendron trichotomum leaves and Rumex gmelini herbes in conscious guinea-pigs challenged with aerosolized ovalbumin | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.phymed.2010.06.014 | - |
dc.identifier.bibliographicCitation | PHYTOMEDICINE, v.18, no.2-3, pp 134 - 142 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000287767800006 | - |
dc.identifier.scopusid | 2-s2.0-78651277041 | - |
dc.citation.endPage | 142 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 134 | - |
dc.citation.title | PHYTOMEDICINE | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | 1-O-caffeoyl glucoside | - |
dc.subject.keywordAuthor | Clerodendron trichotomum | - |
dc.subject.keywordAuthor | Acteoside | - |
dc.subject.keywordAuthor | sRaw | - |
dc.subject.keywordAuthor | Chemical mediators | - |
dc.subject.keywordAuthor | BALF | - |
dc.subject.keywordAuthor | Anti-asthmatic | - |
dc.subject.keywordPlus | CAFFEIC ACID | - |
dc.subject.keywordPlus | ASTHMATIC RESPONSES | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | ANTIGEN CHALLENGE | - |
dc.subject.keywordPlus | HYPERREACTIVITY | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | THERAPIES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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