Binary mixing of micelles using Pluronics for a nano-sized drug delivery system

Abstract

Pluronics with different structural compositions and properties are used for several applications including drug delivery systems We developed a binary mixing system with two Pluronics L121/P123 as a nano sized drug delivery carrier The lamellar forming Pluronic L121 (0 1 wt%) was incorporated with Plutonic P123 to produce nano sized dispersions (in case of 0 1 and 05 wt% P123) with high stability due to Plutonic P123 and high solubilization capacity due to Plutonic L121 The binary systems were spherical and less than 200 nm diameter with high thermodynamic stability (at least 2 weeks) in aqueous solution The CMC of the binary system was located in the middle of the CMC of each polymer In particular the solubilization capacity of the binary system (0 1/0 1 wt%) was higher than mono systems of P123 The main advantage of binary systems is overcoming limitations of mono systems to allow tailored mixing of block copolymers with different physicochemical characteristics These nano sized systems may have potential as anticancer drug delivery systems with simple preparation method high stability and high loading capacity (C) 2010 Elsevier B V All rights reserved