Pathological bolus exposure plays a significant role in eliciting non-cardiac chest pain
DC Field | Value | Language |
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dc.contributor.author | Kim, Beom Jin | - |
dc.contributor.author | Choi, Sung Chul | - |
dc.contributor.author | Kim, Jae J. | - |
dc.contributor.author | Rhee, Jong Chul | - |
dc.contributor.author | Rhee, Poong-Lyul | - |
dc.date.available | 2019-05-30T00:37:07Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22040 | - |
dc.description.abstract | Background and Aim: Pathological bolus exposure is defined in the present study as cases in which all reflux percentage times are above 1.4% of the total reflux number, as revealed by impedance-pH monitoring. The role of pathological bolus exposure in the pathogenesis of non-cardiac chest pain (NCCP) is poorly known. We aimed to classify and characterize NCCP using combined impedance-pH monitoring. Methods: Seventy-five consecutive patients with NCCP were prospectively enrolled from January 2006 to October 2008. All the patients underwent upper endoscopy, esophageal manometry, and 24-h multichannel intraluminal impedance (MII)-pH metering. Results: Sixteen patients (21.3%) had esophageal erosion upon endoscopy. Upon esophageal manometry, 37 patients (49.3%) had esophageal dysmotility. When the patients were classified based on MII-pH metering, 16 (21.3%) showed pathological acid exposure, and 40 (53.3%) showed pathological bolus exposure. The DeMeester score of patients with pathological acid exposure was higher than that of patients with pathological bolus exposure (P = 0.002). There was no significant difference in age, sex, typical esophageal symptoms, presence of esophageal erosion, esophageal dysmotility, improvement with proton pump inhibitor medication, symptom index >= 50%, percentage of time clearance pH below 4 >= 4%, and all reflux time >= 1.4% in the fasting period between the two groups. When the patients were divided into gastroesophageal reflux disease (GERD)-related NCCP and non-GERD-related NCCP groups based on MII-pH metering and upper endoscopy, there was no difference between the two groups. Conclusions: Combined impedance-pH monitoring improves the detection and characterization of NCCP. This study suggests that pathological bolus exposure plays a major role in eliciting NCCP. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Pathological bolus exposure plays a significant role in eliciting non-cardiac chest pain | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1440-1746.2010.06415.x | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.25, no.12, pp 1855 - 1860 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000284589300010 | - |
dc.identifier.scopusid | 2-s2.0-78649544528 | - |
dc.citation.endPage | 1860 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1855 | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | combined impedance-pH monitoring | - |
dc.subject.keywordAuthor | non-cardiac chest pain | - |
dc.subject.keywordAuthor | pathological bolus exposure | - |
dc.subject.keywordPlus | MULTICHANNEL INTRALUMINAL IMPEDANCE | - |
dc.subject.keywordPlus | GASTROESOPHAGEAL-REFLUX DISEASE | - |
dc.subject.keywordPlus | NORMAL VALUES | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordPlus | MANOMETRY | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | ARTICLE | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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