Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-I beta
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong-Wook | - |
dc.contributor.author | Kim, Kee-Beom | - |
dc.contributor.author | Kim, Ji-Young | - |
dc.contributor.author | Lee, Kyu-Sun | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.date.available | 2019-05-30T00:52:55Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22193 | - |
dc.description.abstract | Epigenetic modification plays an important role in transcriptional regulation As a subunit of the INHAT (Inhibitor of histone acetyltransferases) complex, SET/TAF-I beta evidences transcriptional repression activity In this study, we demonstrate that SET/TAF-I beta is abundantly expressed in neuronal tissues of Drosophila embryos It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds SET/TAF-I beta binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes The results of this study show that the knockdown of SET/TAF-I beta by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-I beta as a negative regulator of neuronal development (C) 2010 Elsevier Inc All rights reserved | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-I beta | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.08.093 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.400, no.3, pp 419 - 425 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000282616200023 | - |
dc.identifier.scopusid | 2-s2.0-77956915356 | - |
dc.citation.endPage | 425 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 419 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 400 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | INHAT | - |
dc.subject.keywordAuthor | Neuronal differentiation | - |
dc.subject.keywordAuthor | Retinoic acid | - |
dc.subject.keywordAuthor | SET/TAF-Iβ | - |
dc.subject.keywordPlus | HISTONE ACETYLATION | - |
dc.subject.keywordPlus | NEUROBLASTOMA-CELLS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | NEURITOGENESIS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | SET | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.