Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor
DC Field | Value | Language |
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dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Whang, Wan Kyunn | - |
dc.contributor.author | Kim, Sungun | - |
dc.contributor.author | Bach, Jae-Hyung | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Nguyen, Xuan-Khanh Thi | - |
dc.contributor.author | Nguyen, Thuy-Ty Lan | - |
dc.contributor.author | Jung, Bae Dong | - |
dc.contributor.author | Yamada, Kiyofumi | - |
dc.contributor.author | Nabeshima, Toshitaka | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.available | 2019-05-30T00:56:27Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 1347-8613 | - |
dc.identifier.issn | 1347-8648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22285 | - |
dc.description.abstract | Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviours in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35S]GTP-gamma S binding assay Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | JAPANESE PHARMACOLOGICAL SOC | - |
dc.title | Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1254/jphs.10040SC | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGICAL SCIENCES, v.113, no.4, pp 404 - 408 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000281166400016 | - |
dc.identifier.scopusid | 2-s2.0-77956198470 | - |
dc.citation.endPage | 408 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 404 | - |
dc.citation.title | JOURNAL OF PHARMACOLOGICAL SCIENCES | - |
dc.citation.volume | 113 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | parishin C | - |
dc.subject.keywordAuthor | phencyclidine | - |
dc.subject.keywordAuthor | 5-HT1A receptor | - |
dc.subject.keywordPlus | GASTRODIA ELATA | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | RHIZOMES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CORTEX | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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