Detailed Information

Cited 25 time in webofscience Cited 0 time in scopus
Metadata Downloads

Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics

Full metadata record
DC Field Value Language
dc.contributor.authorPark, Byung-Lae-
dc.contributor.authorPark, Se-Min-
dc.contributor.authorPark, Jong-Sook-
dc.contributor.authorUh, Soo-Taek-
dc.contributor.authorChoi, Jae-Sung-
dc.contributor.authorKim, Yong-Hoon-
dc.contributor.authorKim, Mi-Kgyeong-
dc.contributor.authorChoi, Inseon S.-
dc.contributor.authorChoi, Byoung-Whui-
dc.contributor.authorCho, Sang-Heon-
dc.contributor.authorHong, Chein-Soo-
dc.contributor.authorLee, Yong-Won-
dc.contributor.authorLee, Jae-Young-
dc.contributor.authorPark, Choon-Sik-
dc.contributor.authorShin, Hyoung-Doo-
dc.date.available2019-05-30T01:33:16Z-
dc.date.issued2010-06-30-
dc.identifier.issn1976-6696-
dc.identifier.issn1976-670X-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22371-
dc.description.abstractAspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After genotyping 120 SNPs of the PTGER gene family for the 1(st) cohort study, four SNPs in PTGER1, ten in PTGER3, six in PTGER3, and a haplotype of PTGER2 showed association signals with decreased or increased risk of AIA. Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the 2(nd) cohort study. The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the 2(nd) cohort study. Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics. [BMB reports 2010; 43(6): 445-449]-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY-
dc.titleAssociation of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics-
dc.typeArticle-
dc.identifier.doi10.5483/BMBRep.2010.43.6.445-
dc.identifier.bibliographicCitationBMB REPORTS, v.43, no.6, pp 445 - 449-
dc.identifier.kciidART001451928-
dc.description.isOpenAccessN-
dc.identifier.wosid000279380000010-
dc.identifier.scopusid2-s2.0-77955786606-
dc.citation.endPage449-
dc.citation.number6-
dc.citation.startPage445-
dc.citation.titleBMB REPORTS-
dc.citation.volume43-
dc.type.docTypeArticle-
dc.publisher.location대한민국-
dc.subject.keywordAuthorAspirin intolerant asthma-
dc.subject.keywordAuthorAsthma-
dc.subject.keywordAuthorProstaglandin E receptor(s)-
dc.subject.keywordAuthorSingle nucleotide polymorphism-
dc.subject.keywordPlusLEUKOTRIENE C-4 SYNTHASE-
dc.subject.keywordPlusRECEPTOR SUBTYPE EP3-
dc.subject.keywordPlusPROSTAGLANDIN E-2-
dc.subject.keywordPlusPROSTANOID RECEPTORS-
dc.subject.keywordPlusCYSTEINYL LEUKOTRIENES-
dc.subject.keywordPlusCYCLOOXYGENASE-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusMANAGEMENT-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > College of Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE