Occurrence and Fate of Fetal Lumbar Rib Induced by Scutellariae radix in Rats
DC Field | Value | Language |
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dc.contributor.author | Ko, Eun A. | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Lim, Inja | - |
dc.contributor.author | Yun, Jihyun | - |
dc.contributor.author | Kim, Jung-Ha | - |
dc.contributor.author | Kang, Young-Ku | - |
dc.contributor.author | Kim, Nari | - |
dc.contributor.author | Han, Jin | - |
dc.contributor.author | Bang, Hyoweon | - |
dc.contributor.author | Ko, Jae-Hong | - |
dc.date.available | 2019-05-30T01:35:33Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 1542-9733 | - |
dc.identifier.issn | 1542-9741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22440 | - |
dc.description.abstract | BACKGROUND: This study was conducted to evaluate the occurrence and fate of fetal lumbar rib induced by Scutellariae radix (SR) in rats. METHODS: Water extracts of SR were orally administered to pregnant rats from day 7 to day 17 of gestation at a dose of 186 mg/kg/day, equivalent to 25 g/kg of starting material, representing a 100-fold increase over typical human intake level. RESULTS: The incidence of fetal lumbar rib in the SR-treated group was increased on gestational day 20 and then decreased on postnatal day 50. The weight of fetuses in the SR-treated group tended to be less than that in the control group. Alkaline phosphatase in SR-treated dams was increased on gestational day 20, but was decreased on postnatal day 50. There were no significant differences between the vehicle control and SR-treated groups in maternal body weight, embryological, histopathological, hematological, and serum biochemical changes. CONCLUSIONS: The present data suggest that the appearance of lumbar rib induced by SR is a transient fetal variation rather than teratogenicity or maternal toxicity. Birth Defects Res (Part B) 89:201-206, 2010. (C) 2010 Wiley-Liss, Inc. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Occurrence and Fate of Fetal Lumbar Rib Induced by Scutellariae radix in Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bdrb.20242 | - |
dc.identifier.bibliographicCitation | BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, v.89, no.3, pp 201 - 206 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000279181100004 | - |
dc.identifier.scopusid | 2-s2.0-77953570362 | - |
dc.citation.endPage | 206 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 201 | - |
dc.citation.title | BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY | - |
dc.citation.volume | 89 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Scutellariae radix | - |
dc.subject.keywordAuthor | lumbar rib | - |
dc.subject.keywordAuthor | transient fetal variation | - |
dc.subject.keywordAuthor | teratogenicity | - |
dc.subject.keywordAuthor | maternal toxicity | - |
dc.subject.keywordAuthor | alkaline phosphatase | - |
dc.subject.keywordPlus | TRADITIONAL CHINESE MEDICINE | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN-E | - |
dc.subject.keywordPlus | WOGONIN | - |
dc.subject.keywordPlus | BAICALIN | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | SKELETAL | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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