The tip region of the MacA alpha-hairpin is important for the binding to TolC to the Escherichia coli MacAB-TolC pump
DC Field | Value | Language |
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dc.contributor.author | Xu, Yongbin | - |
dc.contributor.author | Sim, Se-Hoon | - |
dc.contributor.author | Song, Saemee | - |
dc.contributor.author | Piao, Shunfu | - |
dc.contributor.author | Kim, Hong-Man | - |
dc.contributor.author | Jin, Xiao Ling | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Ha, Nam-Chul | - |
dc.date.available | 2019-05-30T01:38:01Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22509 | - |
dc.description.abstract | The tripartite efflux pump MacAB-TolC found in Gram-negative bacteria is involved in resistance to antibiotics. We previously reported the funnel-like hexameric structure of the adaptor protein MacA to be physiologically relevant. In this study, we investigated the role of the tip region of its alpha-hairpin, which forms a cogwheel structure in the funnel-like shape of the MacA hexamer. Mutational and biochemical analyses revealed that the conserved residues located at the tip region of the alpha-hairpin of MacA play an essential role in the binding of TolC. Our findings offer a molecular basis for understanding the drug resistance of pathogenic bacteria. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | The tip region of the MacA alpha-hairpin is important for the binding to TolC to the Escherichia coli MacAB-TolC pump | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.03.097 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.394, no.4, pp 962 - 965 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000276986400017 | - |
dc.identifier.scopusid | 2-s2.0-77950858238 | - |
dc.citation.endPage | 965 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 962 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 394 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Multidrug resistance | - |
dc.subject.keywordAuthor | MacA | - |
dc.subject.keywordAuthor | TolC | - |
dc.subject.keywordAuthor | Assembly model | - |
dc.subject.keywordPlus | MEMBRANE-FUSION PROTEIN | - |
dc.subject.keywordPlus | MULTIDRUG EFFLUX PUMP | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | PERIPLASMIC COMPONENT | - |
dc.subject.keywordPlus | TRANSPORTER | - |
dc.subject.keywordPlus | CHANNEL | - |
dc.subject.keywordPlus | RECONSTITUTION | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | EXPORT | - |
dc.subject.keywordPlus | DRUGS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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