The Analgesic and Anti-inflammatory Effects of 7-Oxosandaracopimaric Acid Isolated from the Roots of Aralia cordata
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae Doo | - |
dc.contributor.author | Lee, Ji Yun | - |
dc.contributor.author | Cho, Bong Jae | - |
dc.contributor.author | Park, Tae Wook | - |
dc.contributor.author | Kim, Chang Jong | - |
dc.date.available | 2019-05-30T01:39:44Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22555 | - |
dc.description.abstract | The root of Aralia cordata is a traditional medicine for the treatment of inflammation, fever, pain, and spasm in the various diseases in Korea. We isolated a dibenzylbutyrolactone diterpene acid, 7-oxosandaracopimaric acid (OSA), from the ether fraction of Aralia cordata MeOH extract, and studied the effect of OSA on phenylquinone (PQ)-induced writhing syndrome and PQ-induced capillary permeability increase, compound 48/80-induced histamine release by peritoneal mast cells, cycloxygenase (COX) activities, and silica-induced RAW 264.7 cell reactive oxygen species production. OSA (30 mg/kg, p.o.) significantly (p < 0.05) inhibited PQ-induced writhes by 25.8% and the PQ-induced capillary permeability increase levels by 33.13% as compared with PQ control. Furthermore, OSA (10 mM) inhibited COX-1 by 22.82 +/- 1.94%, and COX-2 by 15.86 +/- 1.35%, respectively, to the same extent as indomethacin at the same concentration (10 mM). And OSA (3.0 mM) significantly (p < 0.05) inhibited compound 48/80-induced histamine release from rat mast cells, and its activity was similar to that of celebrex (1 mM), but no piracetam (0.1 mM) inhibited them. OSA did not inhibit ROS production in RAW 264.7 cells. These results indicated that OSA has analgesic and anti-inflammatory effects due to its inhibitory effects on capillary permeability, COX activities, and histamine release. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | The Analgesic and Anti-inflammatory Effects of 7-Oxosandaracopimaric Acid Isolated from the Roots of Aralia cordata | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-010-0403-2 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.33, no.4, pp 509 - 514 | - |
dc.identifier.kciid | ART001438326 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000276970700004 | - |
dc.identifier.scopusid | 2-s2.0-77954507858 | - |
dc.citation.endPage | 514 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 509 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 33 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Aralia cordata root | - |
dc.subject.keywordAuthor | 7-Oxosadaracopimaric acid | - |
dc.subject.keywordAuthor | Phenylquinone | - |
dc.subject.keywordAuthor | Compound 48/80 | - |
dc.subject.keywordAuthor | Mast cell | - |
dc.subject.keywordAuthor | Histamine | - |
dc.subject.keywordAuthor | COX | - |
dc.subject.keywordPlus | PERITONEAL MAST-CELLS | - |
dc.subject.keywordPlus | INHIBITORY CONSTITUENTS | - |
dc.subject.keywordPlus | HISTAMINE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PHENYLQUINONE | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | THUNB | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | BARK | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.